NCAA Football: Texas A&M at Alabama
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Clemson's streak of 97 consecutive weeks inside the AP Top 10 has come to an end. Its run of six straight College Football Playoff appearances is likely going to be snapped as well. The Tigers were upset by North Carolina State in Week 4, falling to 2-2 on the season. They will be trying to avoid another loss when they host undefeated Boston College at 7:30 p.m. ET as part of the Week 5 college football schedule. Caesars Sportsbook lists the Tigers as 15-point favorites in the latest Week 5 college football odds.

Is Clemson a team that bettors should be looking to fade? Or are there better opportunities to attack in the Week 5 college football spreads in games such as No. 8 Arkansas vs. No. 2 Georgia (-16.5) or the SEC on CBS matchup between No. 1 Alabama vs. No. 12 Ole Miss (+14.5)? Before making any Week 5 college football picks on those games or others, be sure to see the latest college football predictions and betting advice from SportsLine's proven model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of almost $3,300 for $100 players on its top-rated college football picks against the spread. After going a sizzling 9-3 in Week 4, It also enters Week 5 of the 2021 season on a 81-61 run on all top-rated college football picks. Anyone who has followed it has seen huge returns.

Now, it has turned its attention to the latest Week 5 college football odds from Caesars and locked in picks for every FBS matchup. Head here to see every pick.

Top Week 5 college football predictions

One of the top college football picks the model is recommending for Week 5: Florida covers (-7.5) in its trip to Kentucky on Saturday night. The Gators have covered the spread in both of their conference games so far this season and they have a chance to make it three in a row in this game. They turned on the jets in the second half of a 38-14 blowout against Tennessee last week. Kentucky is unbeaten, but its last three wins have all come by single digits.

Florida's rushing attack averaged 7.1 yards per carry against the Vols, led by quarterback Emory Jones. He had 144 rushing yards on 15 attempts, including a 49-yard scamper. SportsLine's model expects him to have success against Kentucky's defense, which is why the Gators are covering this spread in over 50 percent of simulations. 

Another one of the college football predictions from the model: No. 7 Cincinnati covers as a two-point favorite at No. 9 Notre Dame in a 2:30 p.m. ET kickoff on Saturday. The Bearcats went undefeated during the regular season last year, finishing No. 8 in the polls. They have their sights set on a College Football Playoff berth this time around. Saturday's game at Notre Dame is a must-win game for the Bearcats, who are led by senior quarterback Desmond Ridder

The 6-foot-4 quarterback is the reigning American Athletic Conference Player of the Year. He is off to a strong start this season, completing 54 of 83 passes for 748 yards and seven touchdowns through his first three games. The model expects Cincinnati to pick up the win, as the Bearcats are covering in well over 50 percent of simulations. 

How to make Week 5 college football picks 

The model has also made the call on who wins and covers in every other game on the Week 5 college football schedule, and it's calling for a Top 25 favorite to go down hard. You can only get every pick for every game at SportsLine.

So what college football picks can you make with confidence? And which Top 25 favorite goes down hard? Check out the latest college football odds below, then visit SportsLine to see which teams win and cover the spread, all from a proven computer model that has returned almost $3,300 in profit over the past five-plus seasons, and find out.

Week 5 college football odds (via Caesars)

Here are the college football lines for some of Week 5's most notable matchups:

Saturday, Oct. 2

Arkansas vs. Georgia (-16.5, 48.5) 

Featured Game | Georgia Bulldogs vs. Arkansas Razorbacks

Michigan vs. Wisconsin (-2, 43.5)

Featured Game | Wisconsin Badgers vs. Michigan Wolverines

Louisville vs. Wake Forest (-6.5, 60.5)

Featured Game | Wake Forest Demon Deacons vs. Louisville Cardinals

UL Monroe vs. Coastal Carolina (-34.5)

Cincinnati vs. Notre Dame (+2, 51)

Featured Game | Notre Dame Fighting Irish vs. Cincinnati Bearcats

Ohio State vs. Rutgers (+15.5, 56.5)

Ole Miss vs. Alabama (-14.5, 77.5)

Featured Game | Alabama Crimson Tide vs. Ole Miss Rebels

Oklahoma vs. Kansas State (+10.5, 52.5)

Featured Game | Kansas State Wildcats vs. Oklahoma Sooners

Oregon vs. Stanford (+8, 58)

Featured Game | Stanford Cardinal vs. Oregon Ducks

Florida vs. Kentucky (+8, 55)

Featured Game | Kentucky Wildcats vs. Florida Gators

Louisiana Tech vs. NC State (-19.5, 55)

Featured Game | NC State Wolfpack vs. Louisiana Tech Bulldogs

Baylor vs. Oklahoma State (-4, 49.5)

Featured Game | Oklahoma State Cowboys vs. Baylor Bears

Mississippi State vs. Texas A&M (-7, 47.5)

Featured Game | Texas A&M Aggies vs. Mississippi State Bulldogs

Boston College vs. Clemson (-16, 47.5)

Featured Game | Clemson Tigers vs. Boston College Eagles

Western Kentucky vs. Michigan State (-10.5)

Featured Game | Michigan State Spartans vs. Western Kentucky Hilltoppers

Indiana vs. Penn State (-10.5, 52.5)

Featured Game | Penn State Nittany Lions vs. Indiana Hoosiers

Auburn vs. LSU (-3.5)

Featured Game | LSU Tigers vs. Auburn Tigers

Arizona State vs. UCLA (-3, 55.5)

Featured Game | UCLA Bruins vs. Arizona State Sun Devils

Fresno State vs. Hawaii (+10, 62.5)

Featured Game | Hawaii Rainbow Warriors vs. Fresno State Bulldogs