College football odds, lines, bets, predictions for Week 5, 2021: Computer model picks Florida, Cincinnati

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Clemson's streak of 97 consecutive weeks inside the AP Top 10 has come to an end. Its run of six straight College Football Playoff appearances is likely going to be snapped as well. The Tigers were upset by North Carolina State in Week 4, falling to 2-2 on the season. They will be trying to avoid another loss when they host undefeated Boston College at 7:30 p.m. ET as part of the Week 5 college football schedule. Caesars Sportsbook lists the Tigers as 15-point favorites in the latest Week 5 college football odds.

Is Clemson a team that bettors should be looking to fade? Or are there better opportunities to attack in the Week 5 college football spreads in games such as No. 8 Arkansas vs. No. 2 Georgia (-16.5) or the SEC on CBS matchup between No. 1 Alabama vs. No. 12 Ole Miss (+14.5)? Before making any Week 5 college football picks on those games or others, be sure to see the latest college football predictions and betting advice from SportsLine's proven model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of almost $3,300 for $100 players on its top-rated college football picks against the spread. After going a sizzling 9-3 in Week 4, It also enters Week 5 of the 2021 season on a 81-61 run on all top-rated college football picks. Anyone who has followed it has seen huge returns.

Now, it has turned its attention to the latest Week 5 college football odds from Caesars and locked in picks for every FBS matchup. Head here to see every pick.

Top Week 5 college football predictions

One of the top college football picks the model is recommending for Week 5: Florida covers (-7.5) in its trip to Kentucky on Saturday night. The Gators have covered the spread in both of their conference games so far this season and they have a chance to make it three in a row in this game. They turned on the jets in the second half of a 38-14 blowout against Tennessee last week. Kentucky is unbeaten, but its last three wins have all come by single digits.

Florida's rushing attack averaged 7.1 yards per carry against the Vols, led by quarterback Emory Jones. He had 144 rushing yards on 15 attempts, including a 49-yard scamper. SportsLine's model expects him to have success against Kentucky's defense, which is why the Gators are covering this spread in over 50 percent of simulations.

Another one of the college football predictions from the model: No. 7 Cincinnati covers as a two-point favorite at No. 9 Notre Dame in a 2:30 p.m. ET kickoff on Saturday. The Bearcats went undefeated during the regular season last year, finishing No. 8 in the polls. They have their sights set on a College Football Playoff berth this time around. Saturday's game at Notre Dame is a must-win game for the Bearcats, who are led by senior quarterback Desmond Ridder.

The 6-foot-4 quarterback is the reigning American Athletic Conference Player of the Year. He is off to a strong start this season, completing 54 of 83 passes for 748 yards and seven touchdowns through his first three games. The model expects Cincinnati to pick up the win, as the Bearcats are covering in well over 50 percent of simulations.

How to make Week 5 college football picks

The model has also made the call on who wins and covers in every other game on the Week 5 college football schedule, and it's calling for a Top 25 favorite to go down hard. You can only get every pick for every game at SportsLine.

So what college football picks can you make with confidence? And which Top 25 favorite goes down hard? Check out the latest college football odds below, then visit SportsLine to see which teams win and cover the spread, all from a proven computer model that has returned almost $3,300 in profit over the past five-plus seasons, and find out.