NCAA Football: Texas A&M at Alabama
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College Football Playoff contenders will look to stave off double-digit underdogs during the Week 7 college football schedule. The Week 7 college football odds from Caesars Sportsbook list top-ranked Georgia at -21.5 against No. 11 Kentucky in the 3:30 p.m. ET SEC on CBS matchup. Elsewhere in the Week 7 college football lines, No. 3 Cincinnati is -21.5 against UCF, while No. 2 Iowa is laying 11.5 points against Purdue.

Are those college football spreads worth targeting in your bets this week? And which other lines have value on Saturday? Before making any Week 7 college football picks on those games or others, be sure to see the latest college football predictions and betting advice from SportsLine's proven model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of almost $3,800 for $100 players on its top-rated college football picks against the spread. It also enters Week 7 of the 2021 season on a 19-7 run on all top-rated college football side picks. Anyone who has followed it has seen huge returns.

Now, it has turned its attention to the latest Week 7 college football odds from Caesars and locked in picks for every FBS matchup. Head here to see every pick.

Top Week 7 college football predictions

One of the top college football picks the model is recommending for Week 7: No. 13 Ole Miss covers (-2.5) at Tennessee in a 7:30 p.m. ET matchup on Saturday. Two of the fastest-moving offenses in the country will square off when the Vols host the Rebels. Tennessee is coming off consecutive blowout wins over Missouri and South Carolina, while Ole Miss bounced back from a loss to Alabama with a win over Arkansas. The Razorbacks came up short on a 2-point conversion to close the game, which ended in a 52-51 final.

Ole Miss has been playing an up-tempo style of football for a couple years under Lane Kiffin, while Tennessee is in its first year under Josh Heupel. The Rebels will be happy to get in a track meet with the Vols, who could have trouble keeping up. SportsLine's model has Ole Miss covering the spread in over 60 percent of simulations, while the under (82) is cashing almost 60 percent of the time. 

Another one of the college football predictions from the model: Second-ranked Iowa covers as an 11.5-point favorite against Purdue on Saturday afternoon at 3:30 p.m. ET. The Hawkeyes will be looking to avoid a letdown performance following their massive win over No. 4 Penn State last week. They have jumped to second in the AP poll for the first time since 1985. Purdue, which is coming off a bye, is one of two teams within striking distance of Iowa in the Big Ten West.

The Hawkeyes feature one of the nation's top defenses -- it showed in the come-from-behind win over Penn State. SportsLine's model expects them to record a pair of interceptions against Purdue quarterback Jack Plummer. The Hawkeyes are covering the spread in well over 60 percent of simulations. 

How to make Week 7 college football picks 

The model has also made the call on who wins and covers in every other game on the Week 7 college football schedule, and it's calling for a top-10 team to get a huge scare. You can only get every pick for every game at SportsLine.

So what college football picks can you make with confidence? And which top-10 squad gets a huge scare? Check out the latest college football odds below, then visit SportsLine to see which teams win and cover the spread, all from a proven computer model that has returned almost $3,800 in profit over the past five-plus seasons, and find out.

Week 7 college football odds (via Caesars)

Here are the college football lines for some of Week 7's most notable matchups:

Saturday, Oct. 16

UCF vs. Cincinnati (-20, 56)

Featured Game | Cincinnati Bearcats vs. UCF Knights

Michigan State vs. Indiana (+3, 51.5)

Featured Game | Indiana Hoosiers vs. Michigan State Spartans

Auburn vs. Arkansas (-3.5, 53)

Featured Game | Arkansas Razorbacks vs. Auburn Tigers

Florida vs. LSU (+10, 58.5)

Featured Game | LSU Tigers vs. Florida Gators

Texas A&M vs. Missouri (+8, 61)

Featured Game | Missouri Tigers vs. Texas A&M Aggies

Oklahoma State vs. Texas (-5, 60.5)

Featured Game | Texas Longhorns vs. Oklahoma State Cowboys

Georgia vs. Kentucky (+22.5, 44.5)

Featured Game | Georgia Bulldogs vs. Kentucky Wildcats

BYU vs. Baylor (-4.5, 48)

Featured Game | Baylor Bears vs. BYU Cougars

Purdue vs. Iowa (-12.5, 43)

Featured Game | Iowa Hawkeyes vs. Purdue Boilermakers

Alabama vs. Mississippi State (+17.5, 59)

Featured Game | Mississippi State Bulldogs vs. Alabama Crimson Tide

NC State vs. Boston College (+2, 51)

Featured Game | Boston College Eagles vs. NC State Wolfpack

TCU vs. Oklahoma (-12, 66)

Featured Game | Oklahoma Sooners vs. TCU Horned Frogs

Arizona State vs. Utah (+1, 51)

Featured Game | Utah Utes vs. Arizona State Sun Devils