NCAA Football: Texas A&M at Alabama
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Penn State has not covered the spread in its last six tries against an SEC team. The 10th-ranked Nittany Lions will try to take care of business against No. 22 Auburn on Saturday night. They are listed as five-point favorites in the latest Week 3 college football lines at Caesars Sportsbook. No. 1 Alabama is a 14.5-point favorite against No. 11 Florida in the 3:30 p.m. ET SEC on CBS matchup, one of the top games on the Week 3 college football schedule. No. 23 BYU (+3.5) has a chance to upset No. 19 Arizona State in the nightcap.

Is there value on any of those Week 3 college football spreads? And which other lines have the most value during Saturday's huge slate? Before making any Week 3 college football picks on those games or others, be sure to see the latest college football predictions and betting advice from SportsLine's proven model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of over $3,500 for $100 players on its top-rated college football picks against the spread. It also enters Week 3 of the 2021 season on a 67-50 run on all top-rated college football picks. Anyone who has followed it has seen huge returns.

Now, it has turned its attention to the latest Week 3 college football odds from Caesars and locked in picks for every FBS matchup. Head here to see every pick.

Top Week 3 college football predictions

One of the top college football picks the model is recommending for Week 3: No. 12 Notre Dame (-7.5) covers against Purdue at 2:30 p.m. ET on Saturday. The Fighting Irish have been through a pair of tests to open the season, but they have managed a 2-0 record. They snuck past Florida State in overtime on Labor Day weekend and then picked up a 32-29 victory over Toledo last Saturday.

Purdue is coming off a 49-0 blowout win at Connecticut, but the model has highlighted an overreaction in the betting market. It expects the Fighting Irish to win this game by double digits, as they are covering the spread in almost 60 percent of simulations. The under (58.5) is also coming through with some room for error. 

Another one of the college football predictions from the model: No. 8 Cincinnati covers as a 3.5-point favorite at Indiana. The Bearcats have opened the season with a pair of blowout wins over Miami (Ohio) and Murray State, but neither of those wins are going to elevate them into the College Football Playoff discussion. They have a chance to turn heads on Saturday afternoon in Bloomington.

Indiana was ranked to open the season, but it was blown out at No. 18 Iowa in its opener. The Hoosiers have not faced a non-conference opponent that was ranked this high since hosting No. 2 USC in 1981. SportsLine's model gives Cincinnati the edge, as the Bearcats cover this number in almost 60 percent of simulations. The under cashes well over 70 percent of the time. 

How to make Week 3 college football picks 

The model has also made the call on who wins and covers in every other game on the Week 3 college football schedule, and it's calling for a Top 25 favorite to go down hard. You can only get every pick for every game at SportsLine.

So what college football picks can you make with confidence? And which Top 25 favorite goes down hard? Check out the latest college football odds below, then visit SportsLine to see which teams win and cover the spread, all from a proven computer model that has returned $3,500 in profit over the past five-plus seasons, and find out.

Week 3 College football odds (via Caesars)

Here are the college football lines for some of Week 3's most notable matchups:

Saturday, Sept. 18

Coastal Carolina vs. Buffalo (+10.5, 58)

Featured Game | Buffalo Bulls vs. Coastal Carolina Chanticleers

Cincinnati vs. Indiana (+3, 51)

Featured Game | Indiana Hoosiers vs. Cincinnati Bearcats

Michigan State vs. Miami (FL) (-6.5, 54.5)

Featured Game | Miami (FL) Hurricanes vs. Michigan State Spartans

Northern Illinois vs. Michigan (-27, 54.5)

Featured Game | Michigan Wolverines vs. Northern Illinois Huskies

Virginia Tech vs. West Virginia (-2.5, 50.5)

Featured Game | West Virginia Mountaineers vs. Virginia Tech Hokies

Nebraska vs. Oklahoma (-22, 61.5)

Featured Game | Oklahoma Sooners vs. Nebraska Cornhuskers

New Mexico vs. Texas A&M (-27.5, 51)

Featured Game | Texas A&M Aggies vs. New Mexico Lobos

Purdue vs. Notre Dame (-7, 59)

Featured Game | Notre Dame Fighting Irish vs. Purdue Boilermakers

Georgia Tech vs. Clemson (-28.5, 51)

Featured Game | Clemson Tigers vs. Georgia Tech Yellow Jackets

Alabama vs. Florida (+14.5, 57)

Featured Game | Florida Gators vs. Alabama Crimson Tide

Tulsa vs. Ohio State (-25, 60.5)

Featured Game | Ohio State Buckeyes vs. Tulsa Golden Hurricane

Kent State vs. Iowa (-22.5, 54.5)

Featured Game | Iowa Hawkeyes vs. Kent State Golden Flashes

Georgia State vs. Arkansas (-23, 52.5)

Featured Game | Arkansas Razorbacks vs. Georgia Southern Eagles

South Carolina vs. Georgia (-30.5, 48.5)

Featured Game | Georgia Bulldogs vs. South Carolina Gamecocks

Virginia vs. North Carolina (-9, 65)

Featured Game | North Carolina Tar Heels vs. Virginia Cavaliers

Auburn vs. Penn State (-6.5, 53)

Featured Game | Penn State Nittany Lions vs. Auburn Tigers

Tulane vs. Ole Miss (-14, 73)

Featured Game | Ole Miss Rebels vs. Tulane Green Wave

Arizona State vs. BYU (+2.5, 50.5)

Featured Game | BYU Cougars vs. Arizona State Sun Devils

Iowa State vs. UNLV (+30, 52)

Featured Game | UNLV Rebels vs. Iowa State Cyclones

Fresno State vs. UCLA (-10)

Featured Game | UCLA Bruins vs. Fresno State Bulldogs