College football odds, picks, predictions, best bets for Week 11: Proven computer model loves TCU, Pittsburgh

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The No. 9 Alabama Crimson Tide are going to have a difficult time making the College Football Playoff this season after suffering a crushing loss at then-No. 10 LSU last week. They are still alive for the SEC West title, though, giving them plenty of motivation heading into their matchup with No. 11 Ole Miss during the Week 11 college football schedule. The Rebels also lost to LSU earlier this season, so they will need help to win the division title as well. Alabama is an 11-point road favorite in that 3:30 p.m. ET SEC on CBS matchup, according to the latest Week 11 college football odds at Caesars Sportsbook.

Another marquee matchup on Saturday features No. 6 Oregon vs. No. 25 Washington. The Ducks are 12-point home favorites in the Week 11 college football lines. Before making any Week 11 college football picks on those games or others, be sure to see the latest college football predictions from SportsLine's advanced computer model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past six-plus years, the proprietary computer model has generated a stunning profit of almost $3,000 for $100 players on its top-rated college football picks against the spread. Anyone who has followed it has seen huge returns.

Now, it has turned its attention to the latest Week 11 college football odds from Caesars and locked in picks for every FBS matchup. Head here to see every pick.

Top college football predictions for Week 11

One of the college picks the model is high on in Week 11: Pittsburgh (-4.5) cruises to an easy win at Virginia on Saturday afternoon. The Cavaliers have now lost five of their last six games, scoring 20 points or fewer in five of those contests. They are going to have trouble keeping pace with a Pittsburgh offense that has gone over 30 points on four occasions, including a 45-point outburst against Virginia Tech last month.

Pittsburgh's Israel Abanikanda is the nation's all-purpose yardage leader, and he is expected to return this week after missing last week's upset win over Syracuse. Backup Rodney Hammond Jr. did an admirable job as a replacement, rushing 28 times for 124 yards and a touchdown against the top defense in the ACC. Pittsburgh has a chance to clinch a bowl trip on Saturday, giving the Panthers some added motivation against a struggling opponent.

Another one of the Week 11 college football picks from the model: TCU (+7) covers at Texas in a 7:30 p.m. ET kickoff on Saturday. The betting market refuses to acknowledge the magical season that TCU is having, moving this line from the 6.5-point opener to 7. TCU has one of the most balanced, explosive offenses in the country, led by quarterback Max Duggan and running back Kendre Miller. The Horned Frogs' attack ranks fourth in the country in both total yards (508.7) and points per game (43.1).

TCU has covered the spread at a 7-1-1 clip through its nine games this season, punishing any bettors who step in its way. Texas has already lost three games in 2022 and it is just 1-4 straight up and against the spread in its last five games against TCU. The model believes the Horned Frogs are undervalued again on Saturday night, as they are covering the spread in over 60% of simulations. See which other teams the model likes here.

How to make college football picks for Week 11

The model has also made the call on who wins and covers in every other FBS matchup in Week 11, and it says several top-25 teams will go down hard. You can only get every pick for every game at SportsLine.

So what college football picks can you make with confidence? And which top-25 teams go down hard? Check out the latest college football odds below, then visit SportsLine to see which teams win and cover the spread, all from a proven computer model that has returned almost $3,000 in profit over the past six-plus seasons, and find out.