NCAA Football: Texas A&M at Alabama
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Following a win over Florida and a bye week, the Tennessee Volunteers will take the field on Saturday sporting their highest AP ranking since 2006. No. 8 Tennessee will visit No. 25 LSU in a noon ET kickoff and the Volunteers are 3-point favorites on the road according to the latest Week 6 college football odds from Caesars Sportsbook. In another top-25 matchup that kicks off at noon ET, No. 19 Kansas will host No. 17 TCU and the Jayhawks are 7.5-point home underdogs in this week's college football lines.

There will also be an SEC doubleheader on CBS as No. 2 Georgia (-28.5) hosts Auburn in a 3:30 p.m. ET kickoff followed by No. 2 Alabama (-24) hosting Texas A&M for an 8 p.m. ET start. So which side should you be backing in those four high-profile college football matchups, and what other Week 6 college football spreads should you be targeting on Saturday? Before locking in any Week 6 college football picks on those games or others, be sure to see the latest college football predictions from SportsLine's advanced computer model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past six-plus years, the proprietary computer model has generated a stunning profit of more than $3,100 for $100 players on its top-rated college football picks against the spread. Anyone who has followed it has seen huge returns.

Now, it has turned its attention to the latest Week 6 college football odds from Caesars and locked in picks for every FBS matchup. Head here to see every pick.

Top college football predictions for Week 6

One of the college picks the model is high on in Week 6: Auburn (+28.5) stays within the spread when it faces No. 2 Georgia on Saturday. Auburn head coach Bryan Harsin appears to be on one of the hottest seats in college football but he'll catch the Bulldogs coming off their worst performance of the season thus far last week in a near loss to Missouri.

Georgia trailed by double-digits in the fourth quarter as Stetson Bennett only managed to complete 54.5% of his passes. Now he'll take on an Auburn pass defense that has only allowed two passing touchdowns all season. Opponents have only completed 57.7% of their passes against the Tigers and Auburn only allows 193.6 yards per game through the air.

Kirby Smart's squad has now turned the ball over five times in its last two games and Auburn has generated a trio of turnovers in its last two games. The model is predicting that the Auburn defense helps slow the Georgia passing attack and limits the Bulldogs to 36 points on average, helping the Tigers cover the spread in nearly 70% of simulations.

Another one of the model's top college football picks: No. 7 Oklahoma State (-9) cruises to a blowout win over Texas Tech. The Red Raiders have played a grueling schedule over the past month, facing four straight top-25 opponents. They are coming off a 37-28 loss to then-No. 25 Kansas State and are on the road for the third time in four weeks, so this is a difficult scheduling spot for them.

Oklahoma State has only had to go on the road once this season, taking down then-No. 16 Baylor in a 36-25 win last week. The Cowboys have cruised to a 4-0 record and will be playing in front of an electric crowd on Saturday. Quarterback Spencer Sanders has thrown for nearly 1,100 yards to go along with 11 touchdowns and just two interceptions.

SportsLine's model expects him to have another big day against Texas Tech, totaling more than 290 yards of offense and three touchdowns. His success is one reason why Oklahoma State is covering the spread more than 70% of the time. See which other teams the model likes here.

How to make college football picks for Week 6

The model has also made the call on who wins and covers in every other FBS matchup in Week 6, and it says a Top 25 favorite will go down hard. You can only get every pick for every game at SportsLine.

So what college football picks can you make with confidence? And which Top 25 favorite goes down hard? Check out the latest college football odds below, then visit SportsLine to see which teams win and cover the spread, all from a proven computer model that has returned more than $3,100 in profit over the past six-plus seasons, and find out.

College football odds for Week 6 (via Caesars)

See full Week 6 college football picks, odds, predictions here

Saturday, Oct. 8 

Tennessee at LSU (-3, 65)

Featured Game | LSU Tigers vs. Tennessee Volunteers

Michigan at Indiana (-22.5, 59)

Featured Game | Indiana Hoosiers vs. Michigan Wolverines

TCU at Kansas (+7, 68.5)

Featured Game | Kansas Jayhawks vs. TCU Horned Frogs

Arkansas at Mississippi State (-9.5, 59)

Featured Game | Mississippi State Bulldogs vs. Arkansas Razorbacks

USF at Cincinnati (-27.5, 59)

Featured Game | Cincinnati Bearcats vs. South Florida Bulls

Auburn at Georgia (-28, 49)

Featured Game | Georgia Bulldogs vs. Auburn Tigers

Texas Tech at Oklahoma State (-9.5, 64)

Featured Game | Oklahoma State Cowboys vs. Texas Tech Red Raiders

Utah at UCLA (+3.5, 64.5)

Featured Game | UCLA Bruins vs. Utah Utes

Ohio State at Michigan State (+25.5, 62)

Featured Game | Michigan State Spartans vs. Ohio State Buckeyes

Ole Miss at Vanderbilt (+19, 59.5)

Featured Game | Vanderbilt Commodores vs. Ole Miss Rebels

Washington at Arizona State (+13, 55.5)

Featured Game | Arizona State Sun Devils vs. Washington Huskies

Clemson at Boston College (+20.5, 50)

Featured Game | Boston College Eagles vs. Clemson Tigers

South Carolina at Kentucky (-10.5, 48.5)

Featured Game | Kentucky Wildcats vs. South Carolina Gamecocks

Army at Wake Forest (-15.5, 65)

Featured Game | Wake Forest Demon Deacons vs. Army West Point Black Knights

Kansas State at Iowa State (+2, 46)

Featured Game | Iowa State Cyclones vs. Kansas State Wildcats

BYU at Notre Dame (-3, 52)

Featured Game | Notre Dame Fighting Irish vs. BYU Cougars

Washington State at USC (-11.5, 62)

Featured Game | USC Trojans vs. Washington State Cougars

Florida State at NC State (-3, 52)

Featured Game | NC State Wolfpack vs. Florida State Seminoles

Texas A&M at Alabama (-24, 48)

Featured Game | Alabama Crimson Tide vs. Texas A&M Aggies

Oregon at Arizona (+12, 69.5)

Featured Game | Arizona Wildcats vs. Oregon Ducks