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The Week 0 college football schedule kicks off Saturday and a national title contender is in the first time slot as No. 10 Florida State takes on Georgia Tech in Dublin at noon ET. The latest Week 0 college football odds via the SportsLine consensus list the Seminoles as 10.5-point favorites. Meanwhile in the United States, Nevada hosts SMU at 8 p.m. ET on CBS Sports Network with Preston Stone and the Mustangs listed as massive 27.5-point favorites.

Who should you target in your Week 0 college football bets for those games and others? Before locking in any college football picks for Week 0 of the 2024 season, be sure to see the latest college football predictions from SportsLine's proven model.

The model simulates every FBS college football game 10,000 times. Since its inception, it has generated a profit of well over $2,000 for $100 players on its top-rated college football picks against the spread. It is also coming off a profitable 13-9 season on top-rated spread picks. Anyone who has followed it has seen strong returns. 

Now, it has turned its attention to the latest college football odds for Week 0 and locked in picks for every FBS matchup. Head here to see every pick.

Top college football predictions for Week 0 

One of the top college football picks the model is recommending for Week 0: Florida State and Georgia Tech go Under 55.5 points. Florida State was among the best defensive teams in the country last season. The Seminoles gave up just 19.29 points per game last season, which ranked 18th in the country.

Meanwhile, Georgia Tech was efficient on offense in 2023 and racked up 290 first downs across 13 games, the 32nd-most in the country. The Yellow Jackets will return starting quarterback Haynes King, who threw for 2,842 yards with 27 touchdowns to go along with 737 rushing yards and 10 more TDs last season. Georgia Tech's ability to bleed the clock with first downs is a big reason why the model is projecting the total to stay Under the posted number in 60% of simulations. See which other picks the model likes here.

How to make college football picks for Week 0

The model has also made the call on who wins and covers in both FBS matchups on Saturday, including two spread picks that hit well over 60% of the time. You can only get every pick for every game at SportsLine.

So what college football picks can you make with confidence, and which teams cover well over 60% of the time? Check out the latest college football odds below, then visit SportsLine to see which teams win and cover the spread, all from a proven computer model that has returned well over $2,000 in profit since its inception, and find out.

College football odds for Week 0

See full Week 0 college football picks, odds, predictions here

Saturday, Aug. 24

Florida State vs. Georgia Tech (+10.5, 55.5)

Montana State at New Mexico (+13.5, 54.5)

SMU at Nevada (+27.5, 55.5)

Delaware State at Hawaii (-39.5, 54.5)