Ben Queen / USA TODAY Sports

Ed Orgeron and the LSU Tigers begin their national title defense on Saturday when they host the Mississippi State Bulldogs at Tiger Stadium in the 3:30 p.m. ET SEC on CBS game. Other national title contenders in action on the Week 4 college football schedule include Alabama vs. Missouri, Oklahoma vs. Kansas State and Georgia vs. Arkansas. LSU is an 18-point favorite over Mississippi State, Alabama is giving Missouri 28 points, Oklahoma is laying 28 points against the Wildcats and Georgia is going off as a 27.5-point road favorite over the Razorbacks in the Week 4 college football odds from William Hill.

Which national title contender has the best chance of covering its double-digit spread on Saturday? And which teams should you completely avoid on the Week 4 college football odds board? Before making any Week 4 college football picks on those games or others, be sure to see the latest college football predictions from SportsLine's proven model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past four-plus years, the proprietary computer model has generated a stunning profit of over $3,800 for $100 players on its top-rated college football picks against the spread. It is a stunning 13-1 on top-rated picks through three weeks of the 2020 college football season, returning over $900 in profit already. Anybody who has followed it is way up. 

Now, it has turned its attention to the latest college football odds for Week 4 from William Hill and locked in picks for every FBS matchup. Head to SportsLine to see every pick.

Top Week 4 college football predictions 

One of the top Week 4 college football picks the model is recommending: Georgia (-27.5) goes to Donald W. Reynolds Razorback Stadium and covers the spread in a 4 p.m. ET matchup against Arkansas. The Razorbacks went just 2-10 last season and will debut a new head coach and quarterback this season. Sam Pittman takes over for Chad Morris, while Florida transfer Feleipe Franks will be under center.

And while there's optimism that the Razorbacks will be more competitive in 2020, the model projects that Georgia's ground game will be simply too strong for an Arkansas defense that ranked last in the SEC against the run last season. Zamir White leads Georgia with 93 yards and a score on the ground in the simulations, while Kenny McIntosh (89 yards) and James Cook (77 yards) also make big contributions. The Bulldogs cover almost 60 percent of the time, making them a great value for Week 4 college football bets.

Another one of the top Week 4 college football predictions from the model: Ole Miss (+13.5) covers as a home underdog against Florida on Saturday in a noon ET kickoff that serves as the debut for Lane Kiffin in Oxford.

Matt Corral and John Rhys Plumlee are listed as the co-starters at quarterback for Ole Miss. That could make Kiffin's offense difficult to prepare for in this opener. Corral is the more accomplished passer after completing almost 60 percent of his passes last year. Plumlee, meanwhile, is a dangerous runner who piled up over 1,000 yards and 12 touchdowns on the ground last year. 

The model predicts that the combination helps Ole Miss put up over 350 yards of total offense. And even with Kyle Trask approaching 300 yards passing for the Gators, the model predicts that's enough for Ole Miss to cover in well over 60 percent of simulations, while the under (57) hits almost 70 percent of the time.

How to make Week 4 college football picks 

The model has also made the call on who wins and covers every other FBS game in Week 4, and it also says a favorite goes down hard in a shocking upset this week in the SEC. You can only get every pick for every game at SportsLine.

So what college football picks can you make with confidence in Week 4? And which SEC underdog pulls off a shocking upset? Check out the latest Week 4 college football odds below for some of the week's most notable games, and then visit SportsLine to see which teams win and cover the spread, all from a proven computer model that has returned over $3,800 in profit over the past four-plus seasons, and find out.

Week 4 college football odds (via William Hill)

Georgia Tech at Syracuse (+7.5)
Louisville at Pittsburgh (-3)
Florida at Ole Miss (+13.5)
Kansas State at Oklahoma (-28)
Kentucky at Auburn (-8)
Iowa State at TCU (+3)
West Virginia at Oklahoma State (-8.5)
Texas at Texas Tech (+17.5)
Mississippi State at LSU (-18)
Georgia at Arkansas (+27.5)
Alabama at Missouri (+28)
Tennessee at South Carolina (+3)
Kansas at Baylor (-18.5)
Florida State at Miami (FL) (-11.5)
Vanderbilt at Texas A&M (-30.5)
NC State at Virginia Tech (-9.5)
Troy at BYU (-13.5)