NCAA Football: Texas A&M at Alabama
Gary Cosby Jr / USA TODAY Sports

The Week 9 college football odds from have shifted throughout the week as Saturday's kickoffs approach. The most drastic example comes in No. 1 Clemson vs. Boston College. The Tigers opened -32 at William Hill but are down to -25 after news broke that quarterback Trevor Lawrence will be held out following a positive COVID-19 test. Freshman D.J. Uiagalelei will get the start in his place.

In the Big Ten, No. 13 Michigan is down to -21.5 against Michigan State. That line opened at -24.5, but has dropped as some bettors expect this rivalry matchup to be closer than that. Do those college football lines offer value or should you look elsewhere for your Week 9 college football bets? Before making any Week 9 college football picks, be sure to see the latest college football predictions from SportsLine's proven model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past four-plus years, the proprietary computer model has generated a stunning profit of almost $4,000 for $100 players on its top-rated college football picks against the spread. It is a sizzling 29-19 on top-rated picks through eight weeks of the 2020 college football season, returning over $450 in profit already. Anybody who has followed it is way up. 

Now, it has turned its attention to the latest college football odds for Week 9 from William Hill and locked in picks for every FBS matchup. Head here to see every pick.

Top Week 9 college football predictions 

One of the top Week 9 college football picks the model is recommending: Iowa (-2.5) wins and covers at home against Northwestern. The Hawkeyes are coming off a disappointing 24-20 loss against Purdue in their season-opener. 

Despite their season-opening setback, the Hawkeyes will be confident they can secure their first victory of the season on Saturday. That's because Iowa has been sensational at home, winning seven of its last eight games at Kinnick Stadium. 

Northwestern, meanwhile, has struggled mightily in conference play over the years. In fact, the Wildcats are just 2-9 in their last 11 games against Big Ten opponents. In addition, the Hawkeyes recorded a 20-0 shutout over Northwestern a season ago. The simulations show Iowa's defense holding Northwestern to just 13 points on Saturday, resulting in the Hawkeyes covering the spread well over 60 percent of the time.

Another one of the top Week 9 college football predictions from the model: Texas Tech (+15.5) stays within the spread as the Red Raiders host No. 24 Oklahoma at 8 p.m. ET. A couple trends work in Texas Tech's favor in this matchup. The Red Raiders are 4-0-1 ATS in their last five games as home underdogs. The home team has also covered in 12 of the last 14 matchups between these teams. 

Texas Tech running back SaRodorick Thompson (ribs) got hurt last week but could play on Saturday. SportsLine's simulations project that he'll get 14 carries and has a great chance to score against an Oklahoma defense that is giving up 26.8 points per game. The Red Raiders keep it within the spread in over 60 percent of simulations, while the over (67) clears well over 60 percent of the time. 

How to make Week 9 college football picks 

The model has also made the call on who wins and covers in Week 9, and it is also predicting a major upset in the Big 12. You can only get every pick for every game at SportsLine.

So what college football picks can you make with confidence in Week 9? And which Big 12 underdog will pull off a shocking upset? Check out the latest Week 9 college football odds below, then visit SportsLine to see which teams win and cover the spread, all from a proven computer model that has returned nearly $4,000 in profit over the past four-plus seasons, and find out.

Week 9 college football odds (via William Hill)

Saturday, Oct. 31

Michigan State at Michigan (-21.5)
Wake Forest at Syracuse (+11)
North Carolina at Virginia (+6.5)
UTSA at FAU (-6.5)
Kansas State at West Virginia (-3)
Boston College at Clemson (-25)
Virginia Tech at Louisville (+3.5)
Notre Dame at Georgia Tech (+19.5)
Charlotte at Duke (-10.5)
Coastal Carolina at Georgia State (+3.5)
Ohio State at Penn State (+13)
Memphis at Cincinnati (-6.5)
Oklahoma at Texas Tech (+14.5)
Purdue at Illinois (+7)
Navy at SMU (-14.5)
Northwestern at Iowa (-2.5)
Texas at Oklahoma State (-3)
Temple at Tulane (-2.5)
Louisiana at Texas State (+16.5)
Troy at Arkansas State (-3.5)
TCU at Baylor (+3)
UCF at Houston (+3)
Iowa State at Kansas (+28.5)
San Diego State at Utah State (+7.5)
Western Kentucky at BYU (-28.5)
North Texas at UTEP (+4.5)
Boise State at Air Force (+12.5)
Nevada at UNLV (+12)
Rice at Southern Miss (-3)
LSU at Auburn (+2)
UAB at Louisiana Tech (+9.5)
Ole Miss at Vanderbilt (+18)
Appalachian State at UL-Monroe (+31.5)
Mississippi State at Alabama (-31)
Arkansas at Texas A&M (-10.5)