NCAA Football: Texas A&M at Alabama
Gary Cosby Jr / USA TODAY Sports

Two of the most explosive offenses in the nation are set to square off on Saturday when No. 1 Alabama battles No. 7 Florida in the 2020 SEC Championship Game at 8 p.m. ET. The Gators enter Saturday's showdown on CBS averaging 386.4 passings yards per game, which ranks first in the country. Alabama, meanwhile, is scoring 49.5 points per game on average, the third-best mark in the nation. The Week 16 college football odds from William Hill Sportsbook list the Crimson Tide as 17-point favorites against Florida, up three points from the opening line. 

Alabama is 7-0 against the spread in its last seven games, and the Gators are 1-5 ATS in their last six meetings with the Crimson Tide. Should you back Alabama in your Week 16 college football bets or look elsewhere for value during Championship Week? Before locking in any college football picks for that game or others, be sure to see the latest college football predictions and betting advice from SportsLine's proven model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past four-plus years, the proprietary computer model has generated a stunning profit of over $3,500 for $100 players on its top-rated college football picks against the spread. It is a sizzling 54-34 on all top-rated picks through 15 weeks of the 2020 college football season, returning over $600 in profit already. Anybody who has followed it is way up. 

Now, it has turned its attention to the latest college football odds for Championship Week from William Hill and locked in picks for every FBS matchup. Head here to see every pick.

Top Championship Week college football predictions 

One of the top Championship Week college football picks the model is recommending: No. 14 Northwestern (+18.5) keeps it within the spread against No. 4 Ohio State in the 2020 Big Ten Championship Game on Saturday at noon ET. The Wildcats were 6-1 against the spread this season. They also covered both times they were listed as underdogs. 

Ohio State, meanwhile, failed to cover in two of its last three games. The model shows the Wildcats holding Justin Fields to around 250 passing yards as they cover in over 50 percent of simulations. The under (55.5), meanwhile, hits almost 70 percent of the time. 

Another one of the Championship Week predictions from the model: No. 24 San Jose State (+6.5) covers in the 2020 Mountain West Championship Game against Boise State on Saturday at 4:30 p.m. ET. The Broncos have a ton of experience and are looking to win their 15th conference championship since 1999. San Jose State, meanwhile, is in the midst of its first winning season since 2006 and the Spartans can win their first outright title since 1990 on Saturday.

Boise State has dominated this rivalry over the years, winning 10 consecutive games against San Jose State. However, this isn't the same Spartans team from years past. In fact, San Jose State enters Saturday's title game giving up just 17.5 points per game in 2020, the 13th best mark in the nation.

In addition, QB Nick Starkel has played extremely well for the Spartans, throwing two or more touchdown passes in five games this season. SportsLine's model is calling for Starkel to throw for nearly 250 yards on Saturday, while the defense shuts down Boise State's ground game. The model shows San Jose State covering the spread in over 50 percent of simulations, while the over (55.5) also hits more than 50 percent of the time.

How to make Championship Week college football picks 

The model has also made the call on who wins and covers in every other Championship Week FBS matchup, and it is calling for a shocking upset in one of the conference title games. You can only get every pick for every game at SportsLine.

So what college football picks can you make with confidence? And which underdog should you be all over? Check out the latest college football odds for some of the week's most notable games below, then visit SportsLine to see which teams win and cover the spread, all from a proven computer model that has returned over $3,500 in profit over the past four-plus seasons, and find out.

Championship Week college football odds (via William Hill)

Saturday, Dec. 19

Big Ten Championship: Northwestern vs. Ohio State (-18.5)

Latest Odds: Ohio State Buckeyes -16.5

SEC Championship: Alabama vs. Florida (+17)

Latest Odds: Florida Gators +16.5

Big 12 Championship: Iowa State vs. Oklahoma (-6)

Latest Odds: Iowa State Cyclones +5

ACC Championship: Clemson vs. Notre Dame (+10.5)

Latest Odds: Notre Dame Fighting Irish +11

AAC Championship: Tulsa vs. Cincinnati (-14)

Latest Odds: Cincinnati Bearcats -13.5

Mountain West Championship: Boise State vs. San Jose State (+6.5)

Latest Odds: San Jose State Spartans +6.5

Texas A&M vs. Tennessee (+14)

Latest Odds: Tennessee Volunteers +13.5

Washington State vs. Utah (-10.5)

Latest Odds: Utah Utes -11.5

Air Force vs. Army (-5.5)

Latest Odds: Army West Point Black Knights +2.5

Ole Miss vs. LSU (-1.5)

Latest Odds: LSU Tigers +1

Missouri vs. Mississippi State (+1.5)

Latest Odds: Mississippi State Bulldogs +1.5

Minnesota vs. Wisconsin (-11)

Latest Odds: Wisconsin Badgers -10.5

Penn State vs. Illinois (+14.5)

Latest Odds: Penn State Nittany Lions -16

Stanford vs. UCLA (-7)

Latest Odds: UCLA Bruins -7

Arizona State vs. Oregon State (+7)

Latest Odds: Oregon State Beavers +7.5