The No. 9 Clemson Tigers and the No. 23 North Carolina Tar Heels will both be looking to recover from disappointing finishes to the regular season when they square off in the ACC title game during the Championship Week college football schedule. Clemson had its College Football Playoff hopes dashed in a loss to South Carolina last week, while North Carolina is on a two-game skid heading into Saturday's matchup. The Tigers are 7.5-point favorites in the latest Championship Week college football odds at Caesars Sportsbook. Which team should you be backing with your Championship Week college football bets?

Some of the other key Championship Week college football lines include No. 1 Georgia (-17.5) vs. No. 14 LSU in the SEC Championship (4 p.m. ET, CBS) and No. 2 Michigan (-16.5) vs. Purdue in the Big Ten title game. No. 3 TCU will also be looking to clinch its spot in the playoff field when it faces No. 10 Kansas State as a 1.5-point favorite. Before making any Championship Week college football picks on those games or others, be sure to see the latest college football predictions from SportsLine's advanced computer model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past six-plus years, the proprietary computer model has generated a stunning profit of almost $2,500 for $100 players on its top-rated college football picks against the spread. Anyone who has followed it has seen huge returns.

Now, it has turned its attention to the latest Championship Week college football odds from Caesars and locked in picks for every FBS matchup. Head here to see every pick.

Top college football predictions for Championship Week

One of the college picks the model is high on for Championship Week: Coastal Carolina (+7) easily stays within the spread against Troy in the Sun Belt Championship. The Chanticleers finished the regular season on a disappointing note, losing to James Madison after winning nine of their first 10 games. They were without star quarterback Grayson McCall, who was named the Sun Belt Player of the Year for a record third-straight time earlier this week.

McCall is a game-time decision for this contest, and his return would give Coastal Carolina the edge. Troy has not won many games by this type of margin this season, losing a pair of games outright early in the campaign. The Chanticleers have won 16 of their last 20 conference games and are being disrespected by the betting market heading into this contest-the model has them covering 60% of the time.  

Another one of the Championship Week college football picks from the model: No. 2 Michigan (-16.5) rolls to a blowout win against Purdue in the Big Ten title game on Saturday night at 8 p.m. ET. The Wolverines can solidify their spot in the College Football Playoff with a win over Purdue after stunning the college football world with a blowout win against Ohio State last week. Michigan outscored the Buckeyes 28-3 after halftime en route to a 45-23 win as a 7.5-point underdog.

The Wolverines have one of the top rushing attacks in the country, even with No. 1 running back Blake Corum out with a knee injury. Backup Donovan Edwards rushed for 216 yards against Ohio State, posting touchdown runs of 75 and 86 yards in the fourth quarter. Michigan has covered the spread at a 12-5-1 clip in its last 18 games, while Purdue has only covered twice in its last six games. The Wolverines have covered in 10 of the last 13 matchups between these teams, and the model has them covering in well over 60% of simulations. See which other teams the model likes here.

How to make college football picks for Championship Week

The model has also made the call on who wins and covers in every other FBS matchup during Championship Week, and it says several big underdogs will cover with room to spare. You can only get every pick for every game at SportsLine.

So what college football picks can you make with confidence? And which large underdogs will hang tough? Check out the latest college football odds below, then visit SportsLine to see which teams win and cover the spread, all from a proven computer model that has returned almost $2,500 in profit over the past six-plus seasons, and find out.

College football odds for Championship Week (via Caesars)

See full Championship Week college football picks, odds, predictions here

Saturday, Dec. 3

2022 MAC Championship Game: Toledo vs. Ohio (+1.5, 55)

Featured Game | Ohio Bobcats vs. Toledo Rockets

2022 Big 12 Championship Game: Kansas State vs. TCU (-1.5, 62)

Featured Game | TCU Horned Frogs vs. Kansas State Wildcats

2022 Sun Belt Championship Game: Coastal Carolina vs. Troy (-7.5, 48)

Featured Game | Troy Trojans vs. Coastal Carolina Chanticleers

2022 SEC Championship Game: LSU vs. Georgia (-17.5, 51)

Featured Game | Georgia Bulldogs vs. LSU Tigers

2022 Mountain West Championship Game: Fresno State vs. Boise State (-3, 54)

Featured Game | Boise State Broncos vs. Fresno State Bulldogs

2022 AAC Championship Game: UCF vs. Tulane (-4, 57)

Featured Game | Tulane Green Wave vs. UCF Knights

2022 ACC Championship Game: Clemson vs. North Carolina (+7.5, 63.5)

Featured Game | North Carolina Tar Heels vs. Clemson Tigers

2022 Big Ten Championship Game: Purdue vs. Michigan (-16.5, 52)

Featured Game | Michigan Wolverines vs. Purdue Boilermakers