The best and possibly most highly-anticipated regular-season game of the 2020 college football season is finally here, and on Saturday night you will be able to see it when No. 2 Alabama hosts No. 3 Georgia in the SEC on CBS Game of the Week. The biggest storyline this week was the unknown availability of Crimson Tide coach Nick Saban, who tested positive for COVID-19 on Wednesday, but has now seen three consecutive negative tests that will allow him to be on the field.

The real story of Saturday night's game is one of the nation's best offenses going up against the second-ranked defense in the country. For the first time in a while, those defensive accolades do not belong to Alabama but rather Georgia, which just last week shutout Tennessee in the second half and held it to -1 rushing yard in the game.

Elsewhere around the country, North Carolina is set for its first game as a top-five team since 1997 when it takes on Florida State. The coach that year? Mack Brown. The coach this year? You guessed it, Mack Brown. The Tar Heels have plenty to prove still in this young season, but they have handled their business in ACC play and need to do so again on Saturday.

Our experts at CBS Sports are here to help you navigate what game to play with expert picks both straight up and against the spread. Let's take a look at four key games this weekend. Be sure to stick with CBS Sports throughout the day for college football coverage from the opening kickoff at noon to the final whistle of the Alabama-Georgia game.

Odds via William Hill Sportsbook | All times Eastern

Pittsburgh at No. 13 Miami (-13) -- noon on ACC Network: More than anything, I like the under in this game, thinking that an early kickoff in Hard Rock Stadium sets up for the kind of rock fight that Pitt wants in order to have a shot to win. The Panthers can hit some big plays with Kenny Pickett and the passing game, but they lack the explosiveness to hang in a shootout with Miami. So if I'm thinking it's lower-scoring and we have a double-digit spread, I'm on the underdog as a principle play. Pick: Pitt (+13) -- Chip Patterson

Kentucky at No. 18 Tennessee (-6.5) -- noon on SEC Network: The best thing any bettor can do is learn from their mistakes, and I learned from one last week. What I learned is that I'm never going to trust Tennessee QB Jarrett Guarantano against a good defense again. That kid is just too fast and loose with the football. So, at home against a good Kentucky defense, laying nearly a touchdown, I'm going with the Wildcats. Pick: Kentucky (+6.5) -- Tom Fornelli

Which college football picks can you make with confidence in Week 7, and which SEC team will pull off a shocking upset? Visit SportsLine to see which teams will win and cover the spread -- all from a proven computer model that has returned over $4,200 in profit over the past four-plus seasons -- and find out.

Louisville at No. 4 Notre Dame (-16.5) -- 2:30 p.m. on NBC: I just can't quit Louisville. The Cardinals have shown a lot of reasons -- most of them on defense -- not to be trusted on the road against one of the best teams in the conference, but I think this is a large number for the best offense that the Irish have faced all season. Pick: Louisville (+16.5) -- Chip Patterson

No. 3 Georgia at No. 2 Alabama (-5) -- 8 p.m. on CBS: Give me the Crimson Tide to win and cover. I don't care that Saban's status was up in the air. His philosophy, scheme, game plan and coaching staff all remained the same, which means all that Alabama had to do is not screw things up in practice while he was absent. Mac Jones and Co. will have enough success to get to 30 points against the Georgia defense and force the Bulldogs to keep up more than they've had to do so far this season. It won't happen. Alabama's defense isn't as bad as it played last week and will make life miserable for Stetson Bennett. Pick: Alabama (-5) -- Barrett Sallee