College football Week 5 lines, game odds: Clemson a slight home dog to Louisville

The college football season has cruised past the quarter-pole and we are on to Week 5. The marquee matchup of this week's slate of games is an ACC Atlantic division matchup between Louisville and Clemson, where the Cardinals can all but put the clamps on a division crown with a win.

That's not the only notable game of the week, however. There's plenty to watch this weekend and plenty of spreads to keep an eye on, so here is your early look at this week's lines and game odds.

Lines you need to know

No. 3 Louisville (-1) at No. 5 Clemson: Few teams have impressed more than Louisville this season, but this is going to be the Cardinals' first big road test. Death Valley will be rocking for the 8 p.m. ET kickoff and the Tigers' defense appears to be rounding into form. This is a heavyweight matchup that features two of the best quarterbacks in the country in Lamar Jackson and Deshaun Watson. It's strange to see Clemson as a home dog, considering the Tigers haven't lost at home since 2013 to Florida State, but this line's moved in favor of the Cardinals since open.

Oklahoma (-3.5) at No. 21 TCU: The Big 12's College Football Playoff chances seem to be sitting at slim-to-none right now, but the conference championship is completely up for grabs as there isn't a dominant team that's emerged through four weeks. Oklahoma and TCU have each been handed losses this season by out-of-conference foes, but this is a chance to get a leg up in the conference title race.

No. 7 Stanford (+3) at No. 10 Washington: This feels like it's the battle for the Pac-12 North title with Oregon struggling so far this season. Both teams are coming off of narrow road wins over Pac-12 South opponents last week and oddsmakers are riding with the home field advantage of the Huskies by making them the three-point favorites. Stanford was less than impressive against UCLA last week, but it's still a bit startling to see them as dogs in this spot.

These may raise some eyebrows

No. 8 Wisconsin (+10.5) at No. 4 Michigan: Speaking of startling lines, seeing Wisconsin as a double-digit dog after the beatdown they put on Sparty on the road this past weekend is fairly surprising. Michigan's been phenomenal and dominated Penn State on Saturday, but this feels like the Badgers aren't being given much respect in this spot.

No. 11 Tennessee (-3) at No. 25 Georgia: I know this is Tennessee and the Vols have a tendency to make games far closer than they should, but after the egg Georgia laid in Oxford last week and the Vols big comeback against Florida, I expected this line to be a bit bigger.

Western Michigan (-3.5) at Central Michigan: The Broncos are 4-0 and are coming off of an impressive win over Georgia Southern after opening with two wins over Big Ten foes in the first three games. Central Michigan has the crazy Hail Mary win over Oklahoma State, but struggled in a loss to a bad Virginia team last week. This feels like it should be closer to a touchdown in favor of the Broncos.

Consider staying away

Oregon (-1) at Washington State: I can not stress walking away from this line enough. These are two bad defenses and this game should be appreciated for the absurdity that it will inevitably produce. You know the best way to make yourself not enjoy weird football? By putting money on it. Just enjoy this one free of charge.

Memphis (+14.5) at No. 16 Ole Miss: Memphis has been beating the daylights out of bad teams to start the season, so I don't know if the Tigers are actually good, but giving them 14.5 points seems like a lot even though Ole Miss looked great last week. I don't think we know enough about Memphis to be comfortable taking them in this spot, but if this offense is actually as good as its looked the first three games, then they could give Ole Miss a game.

Northwestern (+12.5) at Iowa: Iowa should win this game handily, but then again the Hawkeyes could only beat Rutgers by seven. I'll be honest, I'm still upset about that after giving Iowa out as a lock so until they find their offensive mojo again, I'll be steering clear of Iowa picks.

CBS Sports Writer

Robby Kalland covers college football and golf for CBS Sports; he also dabbles in boxing, mixed martial arts and other sports. Prior to joining CBS in 2015, Robby spent time working for the Atlanta Hawks,... Full Bio

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