The Duke Blue Devils will take on the Northwestern Wildcats at 4 p.m. ET on Saturday at Wallace Wade Stadium. Both squads are 1-1 on the season after defeating FCS schools last week. Now the two premier athletic institutions will renew a non-conference series that began in 1985. They've split the 20 games they've played thus far with Duke taking the last two games in 2017 and 2018.

David Cutcliffe and Pat Fitzgerald will be familiar with each other having coached five games head-to-head but with the rosters almost entirely turned over since their last meeting, it will have an entirely different feel. The Wildcats are favored by 2.5-points in the latest Duke vs. Northwestern odds from Caesars Sportsbook, and the over-under is set at 49.5. Before entering any Northwestern vs. Duke picks, you'll want to see the college football predictions from the model at SportsLine.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of over $3,500 for $100 players on its top-rated college football picks against the spread. It also enters Week 3 of the 2021 season on a 67-50 run on all top-rated college football picks. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Duke vs. Northwestern. You can head to SportsLine to see its picks. Here are several college football odds for Duke vs. Northwestern:

  • Duke vs. Northwestern spread: Duke +2.5
  • Duke vs. Northwestern over-under: 49.5 points
Featured Game | Duke Blue Devils vs. Northwestern Wildcats

What you need to know about Duke

The Blue Devils made easy work of the North Carolina A&T Aggies last Friday and carried off a 45-17 win. Duke QB Gunnar Holmberg was slinging it as he accumulated 270 passing yards in addition to rushing for two TDs and 30 yards. Holmberg has helped lead a Duke offense that is averaging 506.5 yards per game.

Mataeo Durant has also been a big part of Duke's offense and even though he only managed 41 rushing yards last week, he did score three times. Durant ran for 255 yards and three scores in a loss to Charlotte the week prior and he should be a focal point of the game plan against a Northwestern defense that gave up 326 yards rushing in an opening-week loss to Michigan State.

What you need to know about Northwestern

Meanwhile, Northwestern strolled past the Indiana State Sycamores last Saturday, taking the matchup 24-6. The defense buckled down after struggling against Michigan State, limiting the Sycamores to 169 total yards. And while they didn't do much offensively, the Wildcats did play solid complimentary football with a strong running game.

Evan Hull ran 22 times for 126 yards and two touchdowns, while Anthony Tyus III also carried the ball 10 times for 71 yards. The return game was also a huge factor as the Wildcats averaged 41.5 return yards to help them dominate field position. Look for them to try to follow a similar formula against Duke.

How to make Northwestern vs. Duke picks

The model has simulated Duke vs. Northwestern 10,000 times and the results are in. We can tell you that the model is leaning under and it also says one side of the spread has all the value. You can only see the pick at SportsLine.

So who wins Duke vs. Northwestern? And which side of the spread is a must-back? Visit SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college football picks.