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The Appalachian State Mountaineers will take on the East Carolina Pirates at 7:30 p.m. ET on Thursday at Bank of America Stadium. The Mountaineers ended last year with a 9-3 record, while East Carolina finished with just three wins. The Pirates enter this matchup having lost four of their last five games played on a Thursday. 

The Mountaineers are favored by 10-points in the latest Appalachian State vs. East Carolina odds from Caesars Sportsbook, and the over-under is set at 56. Before entering any East Carolina vs. Appalachian State picks, you'll want to see the college football predictions from the advanced computer model at SportsLine.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of over $3,600 for $100 players on its top-rated college football picks against the spread. It also enters Week 1 of the 2021 season on a 57-37 run on all top-rated college football picks. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Appalachian State vs. East Carolina. You can head to SportsLine to see its picks. Here are several college football odds for Appalachian State vs. East Carolina:

  • Appalachian State vs. East Carolina spread: Appalachian State -10
  • Appalachian State vs. East Carolina over-under: 56 points

What to know about the Appalachian State Mountaineers

After a 9-3 record last year and a win in the Myrtle Beach Bowl, Appalachian State is coming in with an eye to spark another quality season. The Mountaineers have won 15 of their last 18 games heading into Thursday's clash against East Carolina. 

Running back Camerun Peoples led the Mountaineers in rushing a season ago, finishing the 2020 campaign with 1,124 rushing yards. He averaged 6.7 yards per carry last season and found the end zone 12 times. Peoples will lead an Appalachian State rushing attack that averaged 264.9 yards per game on the ground last season, which ranked sixth in the nation.

What to know about the East Carolina Pirates

On the other hand, last year was nothing to brag about for East Carolina (3-6), so the Pirates are looking forward to a new start. The Pirates averaged 173.8 rushing yards per game in 2020 and they'll have leading rusher Rahjai Harris back in the lineup this season. 

East Carolina is just 4-12 in its last 16 games overall. The Pirates have also struggled in season openers, covering the spread just once in their last five games played in Week 1. In addition, East Carolina is 3-17 in its last 20 games when playing as the underdog. 

How to make Appalachian State vs. East Carolina picks

The model has simulated Appalachian State vs. East Carolina 10,000 times and the results are in. We can tell you that the model is leaning over, and it's also generated a point-spread pick that is hitting in well over 50 percent of simulations. You can only see the pick at SportsLine.

So who wins East Carolina vs. Appalachian State? And which side of the spread is a must-back? Visit SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college football picks.