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The Louisville Cardinals and the Florida State Seminoles will face off in an ACC clash at 3:30 p.m. ET on Saturday at Doak Campbell Stadium. FSU is 0-3 while the Cardinals are 2-1, having won their last two games. The Seminoles are 4-3 against the Cardinals since Louisville joined the ACC in 2014.

The Cardinals are favored by 1.5-points in the latest Florida State vs. Louisville odds from Caesars Sportsbook, and the over-under is set at 61.5. Before entering any Louisville vs. Florida State picks, you'll want to see the college football predictions from the model at SportsLine.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of almost $3,000 for $100 players on its top-rated college football picks against the spread. It also enters Week 4 of the 2021 season on a 72-58 run on all top-rated college football picks. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Florida State vs. Louisville. You can head to SportsLine to see its picks. Here are several college football odds for Louisville vs. Florida State:

  • Florida State vs. Louisville spread: Florida State +1.5
  • Florida State vs. Louisville over-under: 61.5 points

What you need to know about Florida State

A win for FSU just wasn't in the stars last Saturday as the team never even grasped a lead. Things couldn't have gone much worse as it lost 35-14 to the Wake Forest Demon Deacons. The last quarter was a mere formality since it was already 35-14 by the third quarter. 

Despite the loss, the Seminoles had strong showings from RB Treshaun Ward, who snatched one receiving TD, and WR Ontaria Wilson, who caught four passes for one TD and 101 yards. One of the most thrilling moments was Wilson's 65-yard TD reception in the second quarter. That play cut the Seminoles' deficit to 10 points, but Wake Forest would score the last 11 points of the game.

What you need to know about Louisville

Meanwhile, the Cardinals beat the UCF Knights 42-35 last Friday. QB Malik Cunningham had a stellar game for Louisville, as he passed for one TD and 265 yards in addition to rushing for two TDs and 99 yards. For the season, Cunningham is one of three players in the nation with at least 700 passing yards and 200 rushing yards.

Complimenting Cunningham in the Cards' rushing attack is freshman RB Jalen Mitchell, who has 213 yards on the year. He's topped 100 yards from scrimmage in back-to-back games and scored his first touchdown of the season last week. Cunningham and Mitchell are one of two pairs of teammates who rank among the top 10 in the ACC in rushing yards, joining Sam Howell and Ty Chandler of North Carolina.

How to make Florida State vs. Louisville picks

The model has simulated Louisville vs. Florida State 10,000 times and the results are in. We can tell you that the model is leaning over, and it's also generated a point-spread pick that hits in over 50 percent of simulations. You can only see the pick at SportsLine.

So who wins Florida State vs. Louisville? And which side of the spread hits over 50 percent of the time? Visit SportsLine now to find out which side of the Louisville vs. Florida State spread you need to jump on Saturday, all from the model that has crushed its college football picks, and find out.