The Ole Miss Rebels face a steep uphill battle in coach Lane Kiffin's first game when they take on the fifth-ranked Florida Gators on Saturday in an SEC matchup at Vaught-Hemingway Stadium. Kiffin takes over a team that went 4-8 in 2019 and is trying to settle on a quarterback. The coach has pieces to work with, and both quarterback options started games last season, so he hopes he can find the formula that helped him go 26-13 in his three seasons at Florida Atlantic. The Gators are 21-5 in two seasons under Dan Mullen and hope to take the step up to elite status with Kyle Trask stabilizing the quarterback spot.

Kickoff is set for Saturday at noon ET in Oxford, Miss. William Hill lists the Gators as 13.5-point favorites in the latest Florida vs. Ole Miss odds, while the over-under for total points scored is 57. Before making any Ole Miss vs. Florida picks, check out the college football predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past four-plus years, the proprietary computer model has generated a stunning profit of over $3,800 for $100 players on its top-rated college football picks against the spread. It is a sizzling 13-1 on top-rated picks through three weeks of the 2020 college football season, returning over $900 in profit already. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Mississippi vs. Florida. You can visit SportsLine now to see the picks. Here are the college football odds from William Hill and trends for Mississippi vs. Florida:

  • Florida vs. Ole Miss spread: Gators -13.5
  • Florida vs. Ole Miss over-under: 57
  • Florida vs. Ole Miss money line: Gators -550, Rebels +425
  • UF: QB Kyle Trask topped 250 passing yards in five straight games to close the 2019 season. 
  • MISS: QB John Rhys Plumlee rushed for 140 yards or more four times last season. 

Why Florida can cover

The Gators are 6-1 against the spread in their last seven conference games, and the Rebels have won just six SEC games over the past three seasons. Florida averaged 33.6 points in its last 10 games last season after Trask took over at quarterback. The senior completed 67 percent of his passes for 2,941 yards and 25 touchdowns and he has a bevy of weapons at his disposal. All-SEC tight end Kyle Pitts is the leading returning receiver, and he is one of the nation's top tight ends, posting 54 catches for 649 yards and five touchdowns in 2019.

Florida is 8-3 ATS in its last 11 road games, and receivers Trevon Grimes (14.9-yard average on 33 catches), Jacob Copeland (13 on 21) and Kadarius Toney (19.4 on 10) can make huge plays. The UF defense ranked ninth in the nation overall in 2019 and has seven starters back, including linebacker Ventrell Miller, who was second on the team with 55 tackles. 

Why Ole Miss can cover

The Rebels are 6-2 against the spread in their last eight games, and Kiffin has game-tested signal-callers in Matt Corral and Plumlee. Both saw plenty of action last year, and Plumlee led the team in rushing (1,023 yards) but had trouble with his passing accuracy. Corral completed 59 percent of his passes for 1,362 yards, while Plumlee was good on just 52.7 percent of his attempts. Kiffin will try to mold one into the all-around threat he prefers.

Ole Miss has covered the spread in four of its past five as an underdog, and running back Jerrion Ealy had a strong debut season, averaging 6.9 yards per carry in posting 722 yards. Elijah Moore is the top returning receiver after hauling in 67 passes for 850 yards and eight scores. Linebackers Lakia Henry and Jacquez Jones are the heart of the defense, Sam Williams had six sacks in 2019 and end Tariqious Tisdale leads a stout but inexperienced front.  

How to make Florida vs. Ole Miss picks

SportsLine's model is leaning under on the total, with projections showing Florida's running game barely clearing 100 yards and the Ole Miss quarterbacks combining for under 200 passing yards. It has also generated an against-the-spread pick that cashes in well over 60 percent of simulations. You can only get the pick at SportsLine

So who wins Ole Miss vs. Florida? And which side of the spread hits well over 60 percent of the time? Visit SportsLine now to see which side of the Florida vs. Ole Miss spread to back, all from the advanced model that is up over $3,800 on its top-rated college football spread picks, and find out.