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The Rice Owls will take on the Houston Cougars at 6:30 p.m. ET on Saturday at Rice Stadium. Rice is 0-1 after an opening week loss to Arkansas, while Houston is also 0-1 after losing to Texas Tech in Week 1. The two campuses are separated by just five miles and Houston has dominated the series, winning five straight and posting a 31-11 all-time record.

The Cougars are favored by eight points in the latest Rice vs. Houston odds from Caesars Sportsbook, and the over-under is set at 53. Before you make any Houston vs. Rice picks, you'll want to see the college football predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of over $3,500 for $100 players on its top-rated college football picks against the spread. It also enters Week 2 of the 2021 season on a 63-45 run on all top-rated college football picks. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Rice vs. Houston. You can head to SportsLine to see its picks. Here are several college football odds for Houston vs. Rice:

  • Rice vs. Houston spread: Rice +8
  • Rice vs. Houston over-under: 53 points
Featured Game | Rice Owls vs. Houston Cougars

What you need to know about Rice

The Owls have to be hurting after a devastating 38-17 loss at the hands of the Arkansas Razorbacks last week. This game was 10-7 at the break, but unfortunately for Rice, it sure didn't stay that way. Rice's defeat came about despite a quality game from WR August Pitre III, who caught four passes for one TD and 97 yards.

The Owls rotated quarterbacks with Wiley Green getting the start and Luke McCaffrey checking in for several series. Green struggled as he threw three interceptions while McCaffrey -- who is the younger brother of Christian -- was able to move down the field with both his arm and his legs. Rice figures to use the two-QB system at least for the time being as each quarterback brings a different skill set to the offense.

What you need to know about Houston

Meanwhile, the matchup between Houston and the Texas Tech Red Raiders last week was not a total blowout, but with Houston falling 38-21, it was darn close to turning into one. The Cougars were up 14-0 at the end of the first quarter but couldn't hold onto the lead. No one had a standout game offensively for Houston, but it got scores from WR Nathaniel Dell and TE Seth Green.

QB Clayton Tune looked completely overmatched against a Power 5 defense as he tossed four interceptions. He was able to put some points on the board as he also accounted for three total touchdowns -- two through the air and one on the ground. He and the Cougars will be hoping for more consistency against Rice as Houston has a 23.6-point average margin of victory over their last five head-to-head matchups.

How to make Rice vs. Houston picks

The model has simulated Houston vs. Rice 10,000 times and the results are in. We can tell you that the model is leaning under, and it's also generated a point-spread pick that hits in well over 50 percent of simulations. You can only see the pick at SportsLine.

So who wins Houston vs. Rice? And which side of the spread hits well over 50 percent of the time? Visit SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college football picks.