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Houston travels to New Orleans, La. to play the Tulane Green Wave on Thursday night. The Cougars are fresh off a 45-10 victory against Tulsa, improving to 4-1 on the year. Tulane lost to East Carolina 52-29, falling to 1-4 on the season. Houston has a 2-2 mark against the spread this season against FBS competition, while Tulane is 1-3 ATS.

Kickoff from Yulman Stadium is set for 7:30 p.m. ET. The latest Houston vs. Tulane odds from Caesars Sportsbook list the Cougars as 6.5-point favorites, up 2.5 points from the opening line. The over-under for total points is set at 60. Before locking in any Tulane vs. Houston picks, be sure to see the college football predictions and betting advice from SportsLine's proven model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of almost $3,400 for $100 players on its top-rated college football picks against the spread. It also enters Week 6 of the 2021 season on a 12-4 run on all top-rated college football side picks. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Houston vs. Tulane and it just revealed its CFB picks and predictions. Visit SportsLine now to see the model's picks. Now, here are the college football odds and betting lines for Tulane vs. Houston:

  • Houston vs. Tulane spread: Houston -6.5
  • Houston vs. Tulane over-under: 60 points
  • Houston vs. Tulane money line: Tulane +205, Houston -250
  • HOU: The Over is 4-0 in Houston's last four vs. a team with a losing record
  • TULN: The Green Wave are 6-0 ATS in their last 6 games as a home underdog 
Featured Game | Tulane Green Wave vs. Houston Cougars

Why Houston can cover

Junior quarterback Clayton Tune has completed 71 percent of his passes for 970 yards with seven touchdowns. In the season opener against Texas Tech, Tune struggled and threw four interceptions. Since then Tune has played better and limited his turnovers. Over the past four games, Tune has tossed four touchdowns to only two interceptions.

Over the past two weeks against Navy and Tulsa, Tune has gone 39 of 54 for 498 yards and three touchdowns. The Texas native has shown that if he takes care of the ball, the Cougar offense will have plenty of chances to score. The Tulane defense also allows 275 yards through the air. 

Why Tulane can cover

Tulane has a running back committee that is led by sophomore Cameron Carroll. Carroll has 42 carries for 204 yards with two touchdowns. The sophomore running back had his best game of the season against East Carolina. Carroll had 147 total scrimmage yards, making plays on the ground and through the air. He had nine carries for 80 yards while catching two passes for 67 yards.

Sophomore Ygenio Booker is a dual-threat back for Tulane. Booker has 17 carries for 88 yards with 12 catches for 57 yards a score. The Florida native is averaging 5.2 yards per rush. Freshman quarterback Michael Pratt leads the Green Wave offense with four rushing touchdowns. Tulane will need its rushing attack to have success on Thursday night. 

How to make Tulane vs. Houston picks

SportsLine's model is leaning over on the total, projecting 63 combined points. It also has generated an against-the-spread pick that hits in over 60 percent of simulations. You can get the pick over at SportsLine.

So who wins Houston vs. Tulane? And which side of the spread hits over 60 percent of the time? Visit SportsLine now to see which side of the Tulane vs. Houston spread to back, all from the advanced model that is up almost $3,400 on its top-rated college football spread picks, and find out.