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The Iowa State Cyclones and the Kansas Jayhawks will face off for their first win in Big 12 play at 7 p.m. ET on October 2 at Jack Trice Stadium. Iowa State stumbled out of the gates a bit in 2021, but could start its turnaround in conference play this week against Kansas. The Jayhawks have been a national punching bag in recent years, and are still looking for their first FCS win this season. Although its results are familiar to previous seasons, the Kansas offense has taken a big step forward from last year, and averages nearly 100 more yards per game so far. Iowa State has received the benefit of the doubt in the national rankings, but needs to come out of this week with a win. 

The Cyclones are favored by 34 points in the latest Iowa State vs. Kansas odds from Caesars Sportsbook, and the over-under is set at 57.5. Before entering any Kansas vs. Iowa State picks, you'll want to see the college football predictions from the model at SportsLine.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of almost $3,300 for $100 players on its top-rated college football picks against the spread. After going a sizzling 9-3 in Week 4, It also enters Week 5 of the 2021 season on an 81-61 run on all top-rated college football picks. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Iowa State vs. Kansas and just revealed its picks and analysis. You can head to SportsLine now to see its picks. Here are several college football odds and betting lines for Iowa State vs. Kansas:

  • Iowa State vs. Kansas spread: Iowa State -34
  • Iowa State vs. Kansas over-under: 58 points
  • Iowa State: 5-0 overall and 3-2 against the spread vs. Kansas under Campbell
  • Kansas: 4-3 ATS as underdogs of 30 points or more

What you need to know about Iowa State

Brock Purdy has been considered one of the nation's better college quarterbacks, but has had mixed results in his performances this season. He's had back-to-back games in which he's thrown for at least 260 yards, but had a horrendous showing on September 11 against Iowa. Last season against Kansas, Purdy threw for 239 yards with two scores and an interception.

Junior running back Breece Hall had over 1,500 yards rushing last season, and is off to another fast start in 2021. In 87 attempts, Hall has averaged 4.9 yards per carry and has three plays that resulted in at least 30-yards or more. The Jayhawks have been one of the worst teams in the country at stopping runs that result in explosive plays.

What you need to know about Kansas

Much of the Jayhawks pickup on offense is thanks to the play of North Texas QB transfer Jason Bean. Bean cleared the 300-yard plateau after he threw for just 57 yards in the prior week against Baylor. Bean is Kansas' rushing leader by a wide margin as well, with 272 yards so far this season.

Bean should be on the move again this week, as Iowa State has come away with 11 sacks so far in 2021. Junior defensive end Will McDonald leads the pass rush with 3.5 sacks but Kansas has been middle-of-the-road up front on its offensive line. Both the Cyclones and Jayhawks have been underwhelming offensively on third down, and neither has converted better than 35-percent of its chances in 2021.

How to make Iowa State vs. Kansas picks

The model has simulated Iowa State vs. Kansas 10,000 times and the results are in. We can tell you that the model is leaning over on the point total, and it's also generated a point-spread pick that is hitting in well over 50 percent of simulations. You can only see the pick at SportsLine.

So who wins Kansas vs. Iowa State? And which side of the spread hits in well over 50 percent of simulations? Visit SportsLine now to see which side of the Iowa State vs. Kansas spread to jump on, all from the advanced model that is on an 81-61 run on top-rated picks, and find out.