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A Big 12 battle is on tap Saturday between the No. 6 Oklahoma State Cowboys and the No. 17 Iowa State Cyclones at 3:30 p.m. ET at Boone Pickens Stadium. Oklahoma State is 3-0 overall and 2-0 at home, while Iowa State is 3-1 overall and 1-0 on the road. The Cowboys are 5-1 in their last six home games against Iowa State. 

The Cyclones, meanwhile, are 15-5-2 against the spread in their last 22 games following an against-the-spread win. Oklahoma State is favored by 3.5-points in the latest Oklahoma State vs. Iowa State odds from William Hill, and the over-under is set at 52. Before you make any Iowa State vs. Oklahoma State picks, check out the college football predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past four-plus years, the proprietary computer model has generated a stunning profit of over $4,100 for $100 players on its top-rated college football picks against the spread. It is a sizzling 25-13 on top-rated picks through seven weeks of the 2020 college football season, returning over $700 in profit already. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Iowa State vs. Oklahoma State. You can visit SportsLine now to see the picks. Here are the college football odds from William Hill and trends for Oklahoma State vs. Iowa State:

  • Iowa State vs. Oklahoma State spread: Oklahoma State -3.5
  • Iowa State vs. Oklahoma State over-under: 52 points
  • Iowa State vs. Oklahoma State money line: Oklahoma State -160, Iowa State +140

What you need to know about Iowa State

The Cyclones have rebounded from a season-opening loss to Louisiana to reel off three straight wins, including a 31-15 triumph over Texas Tech two weeks ago. Quarterback Brock Purdy passed for 302 yards and two touchdowns, while running back Breece Hall gained 135 yards on 27 carries and scored twice against the Red Raiders. Purdy has thrown for 912 yards and four touchdowns against just one interceptions this season. Hall has 531 rushing yards on 93 carries and eight touchdowns.

The Cyclones are 5-1 in their last six games against an opponent from the Big 12. However, Iowa State is 1-5 in its last six games on the road against Oklahoma State. 

What you need to know about Oklahoma State

The Cowboys remain unbeaten after thumping Kansas, 47-7, in their last outing. Oklahoma State scored 44 straight points and racked up 400 more yards of offense than the Jayhawks, going for 593 against Kansas' 193. Quarterback Shane Illingworth passed for 265 yards and three touchdowns, while running back Chuba Hubbard rushed for 145 yards on 20 carries and two touchdowns.

Oklahoma State owns one of the best defenses in college football, allowing just 274.3 yards and 9.0 points per game. In addition, the Cowboys have covered the spread in six of their last seven games against Big 12 opponents. 

How to make Iowa State vs. Oklahoma State picks

SportsLine's model is leaning under on the total, and it has also generated an against-the-spread pick that hits in well over 50 percent of simulations. You can only get the pick at SportsLine.

So who wins Iowa State vs. Oklahoma State? And which side of the spread hits well over 50 percent of the time? Visit SportsLine now to see which side of the Oklahoma State vs. Iowa State spread to jump on Saturday, all from the advanced model that is up over $4,100 on its top-rated college football spread picks, and find out.