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No. 8 Oklahoma State has had several close calls this season, but the Cowboys keep winning and covering. They're 6-0 overall and have a 4-1 ATS record against FBS competition. Despite still being in the Big 12 and College Football Playoff hunt, the Cowboys find themselves as road underdogs when they travel to Ames to take on Iowa State (4-2) on Saturday afternoon.

Kickoff is set for 3:30 p.m. ET. Caesars Sportsbook lists the Cyclones as seven-point home favorites in the latest Iowa State vs. Oklahoma State odds. The over-under for total points is set at 47. Before making any Oklahoma State vs. Iowa State picks, you'll want to see the college football predictions from the model at SportsLine.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of almost $3,700 for $100 players on its top-rated college football picks against the spread. It also enters Week 8 of the 2021 season on a 22-9 run on all top-rated college football side picks. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Iowa State vs. Oklahoma State. You can head to SportsLine to see its picks. Here are several college football odds for Oklahoma State vs. Iowa State:

  • Iowa State vs. Oklahoma State spread: Iowa State -7
  • Iowa State vs. Oklahoma State over-under: 47 points
  • Iowa State vs. Oklahoma State money line: Cyclones -270, Cowboys +220
Featured Game | Iowa State Cyclones vs. Oklahoma State Cowboys

What you need to know about Iowa State

The Cyclones were viewed as possible playoff contenders before the season, but two early-season losses have taken them out of that conversation. They can still make noise in the Big 12, however, and they're about to be tested with matchups against Oklahoma State, Texas and Oklahoma all on the slate in the next five weeks. 

Brock Purdy and Breece Hall remain one of the best QB-RB duos in the country. Purdy is completing 73.9 percent of his passes, while Hall has an impressive 134-748-10 rushing line for the season. The Cyclones are also tough defensively, giving up just 16.3 points per game. They have a tough task covering the seven-point spread against a top-10 squad, but if they can play up to their preseason billing, they'll have a shot. 

What you need to know about Oklahoma State

The Cowboys have a pretty good running back of their own in Jaylen Warren, who was the key player on offense in last weekend's win against the Longhorns. The redshirt senior picked up 193 yards on the ground on 33 carries in the 32-24 win. Head coach Mike Gundy needs Warren to be on top of his game because quarterback Spencer Sanders has not been. Over the last two games, Sanders has completed just 58 percent of his passes with two touchdowns and four interceptions.

On defense, the Cowboys have a couple of players that have been difference-makers this season. Senior safety Kolby Harvell-Peel has two interceptions so far this season and senior linebacker Malcolm Rodriguez has two forced fumbles. Oklahoma State has been one of the nation's best defenses at getting off the field on third downs, and have only allowed opponents to convert less that 29-percent of them.

How to make Oklahoma State vs. Iowa State picks

The model is leaning under on the total, and it's also generated a point-spread pick that is hitting in well over 50 percent of simulations. You can only see the pick at SportsLine.

So who wins Iowa State vs. Oklahoma State? And which side of the spread hits well over 50 percent of the time? Visit SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college football picks