The Iowa Hawkeyes will take on the Colorado State Rams at 3:30 p.m. ET on Saturday at Kinnick Stadium. The Hawkeyes are 3-0 and ranked fifth in the AP Poll, while Colorado State is 1-2 and coming off its first win of the season. This will be the first-ever meeting between these teams.

The Hawkeyes are favored by 23.5-points in the latest Iowa vs. Colorado State odds from Caesars Sportsbook, and the over-under is set at 44.5. Before entering any Iowa vs. Colorado State picks, you'll want to see the college football predictions from the model at SportsLine.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of almost $3,000 for $100 players on its top-rated college football picks against the spread. It also enters Week 4 of the 2021 season on a 72-58 run on all top-rated college football picks. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Iowa vs. Colorado State. You can head to SportsLine to see its picks. Here are several college football odds for Iowa vs. Colorado State:

  • Iowa vs. Colorado State spread: Iowa -23.5
  • Iowa vs. Colorado State over-under: 44.5 points
Featured Game | Iowa Hawkeyes vs. Colorado State Rams

What you need to know about Colorado State

It was all tied up 3-3 at the half for Colorado State and the Toledo Rockets last Saturday, but the Rams stepped up in the second half for a 22-6 win. The game was a field goal-fest as 21 of the 28 total points came via field goals, with the Rams making five of them. The win marked Colorado State's first non-conference road victory since a 2015 win over UTSA.

Colorado State's offensive game plan revolves around QB Todd Centeio. The fifth-year senior has thrown for 652 yards and three touchdowns while also rushing for 147 yards on 4.7 yards per carry. Centeio is supported by RB David Bailey as the 240-pound transfer from Boston College has accounted for four of the Rams' six offensive touchdowns.  

What you need to know about Iowa

Meanwhile, you're bound to get a positive result if you outscore your opponent every quarter, and that's exactly how it played out for Iowa last Saturday. The Hawkeyes were the clear victors by a 30-7 margin over the Kent State Golden Flashes. RB Tyler Goodson had a stellar game for Iowa as he rushed for three TDs and 153 yards on 22 carries.

But the real MVP of the Hawkeyes is their defense, which has allowed just three total touchdowns thru as many games. Iowa's 10 points allowed per game leads the Big Ten and ranks fourth in FBS. The defense is led by defensive linemen Lukas Van Ness and Joe Evans, both of whom are tied for second in the conference with 3.0 sacks apiece.

How to make Iowa vs. Colorado State picks

The model has simulated Iowa vs. Colorado State 10,000 times and the results are in. We can tell you that the model is leaning over, and it also says one side of the spread hits well over 50 percent of the time. You can only see the pick at SportsLine.

So who wins Iowa vs. Colorado State? And which side of the spread hits in well over 50 percent of simulations? Visit SportsLine now to find out which side of the spread you need to jump on, all from the expert who has crushed his college football picks, and find out.