A Big Ten battle is on tap Saturday between the Penn State Nittany Lions and the Iowa Hawkeyes at 3:30 p.m. ET at Beaver Stadium. Penn State is 0-4 overall and 0-2 at home, while Iowa is 2-2 overall and 1-1 on the road. The Nittany Lions are 4-1 against the spread in their last five games as a home underdog. 

The Hawkeyes, meanwhile, are 5-1 against the spread in their last six road games against a team with a losing home record. The Hawkeyes are favored by two-points in the latest Penn State vs. Iowa odds from William Hill Sportsbook, and the over-under is set at 46.5. Before you make any Iowa vs. Penn State picks, check out the college football predictions from the SportsLine Projection Model.

The model simulates every FBS college football game 10,000 times. Over the past four-plus years, the proprietary computer model has generated a stunning profit of almost $3,900 for $100 players on its top-rated college football picks against the spread. It is a sizzling 39-21 on top-rated picks through 11 weeks of the 2020 college football season, returning over $1,000 in profit already. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Iowa vs. Penn State. You can visit SportsLine now to see the picks. Here are the college football odds from William Hill and trends for Penn State vs. Iowa:

  • Iowa vs. Penn State spread: Hawkeyes -2
  • Iowa vs. Penn State over-under: 46.5 points
  • Iowa vs. Penn State money line: Hawkeyes -125, Nittany Lions +105

What you need to know about Iowa

The Hawkeyes opened the season with close losses to Purdue and Northwestern, but have since dominated Michigan State and Minnesota by a combined 84-14 score. Running backs Tyler Goodson and Mekhi Sargent combined for 228 yards and three touchdowns against the Golden Gophers. Goodson has back-to-back 100-yard games and five rushing touchdowns this season.

With one more victory, coach Kirk Ferentz will join Woody Hayes (152), Bo Schembechler (143), and Amos Alonzo Stagg (115) as the only coaches to win 100 games in the Big 10.

What you need to know about Penn State

The winless Nittany Lions' defense is struggling, with the 30 points scored by Nebraska last week the fewest allowed this season, but Penn State still lost 30-23. Penn State's offense racked up 501 yards and almost overcame a 21-point halftime deficit, with reserve quarterback Will Levis throwing for a career-high 219 yards after replacing Sean Clifford in the second quarter.

Penn State has won the last six meetings and 11 of the 20 contests against Iowa since the Nittany Lions joined the Big Ten in 1993. In addition, Penn State is 4-1 against the spread in its last five home games against the Hawkeyes. 

How to make Iowa vs. Penn State picks

SportsLine's model is leaning under on the total. In fact, it says that no running back on either team will rush for more than 45 yards. It also says one side of the spread hits in well over 60 percent of simulations. You can only get the pick at SportsLine

So who wins Iowa vs. Penn State? And which side of the spread cashes in well over 60 percent of simulations? Visit SportsLine now to see which side of the Penn State vs. Iowa spread to jump on, all from the advanced model that is up almost $3,900 on its top-rated college football spread picks, and find out.