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A Big Ten battle is on tap Saturday between the Purdue Boilermakers and the Iowa Hawkeyes at 3:30 p.m. ET at Ross-Ade Stadium. The Hawkeyes are 1-4 against the spread in their last five games against Purdue. The Boilermakers, meanwhile, are 7-1 against the spread in their last eight games. 

The Hawkeyes are favored by three-points in the latest Purdue vs. Iowa odds from William Hill, and the over-under is set at 53. Before you make any Iowa vs. Purdue picks, check out the college football predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past four-plus years, the proprietary computer model has generated a stunning profit of over $4,100 for $100 players on its top-rated college football picks against the spread. It is a sizzling 25-13 on top-rated picks through seven weeks of the 2020 college football season, returning over $700 in profit already. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Iowa vs. Purdue. You can visit SportsLine now to see the picks. Here are the college football odds from William Hill and trends for Purdue vs. Iowa:

  • Iowa vs. Purdue spread: Iowa -3
  • Iowa vs. Purdue over-under: 53 points
  • Iowa vs. Purdue money line: Iowa -150, Purdue +130

What you need to know about Iowa

The Hawkeyes are coming off a 10-3 season, which included a three-game win streak to end the regular season and a 49-24 win against Southern Cal in the Holiday Bowl. In 2020, Iowa should be a traditional Iowa team: fundamentally sound that will dominate opponents at the line of scrimmage. 

Iowa returns running back Tyler Goodson and explosive wideout Ihmir Smith-Marsette, who scored receiving, rushing and kick-return touchdowns in the Holiday Bowl. Spencer Petras is likely taking over the QB1 spot, and linebackers Djimon Colbert and Nick Niemann return after productive 2019 seasons.

What you need to know about Purdue

Boilermakers coach Jeff Brohm tested positive for COVID-19 earlier this week and won't be on the sideline for the Iowa game. Co-offensive coordinator/quarterbacks coach Brian Brohm will serve as the team's acting head coach and will call the plays against the Hawkeyes.

Purdue is coming off a 4-8 season and returns wide receiver Rondale Moore, who decided to return to the Boilermakers after initially announcing he was opting out of the season to prepare for the NFL Draft. Moore has had an extremely productive career thus far at Purdue, recording 143 receptions for 1,645 yards and 14 touchdowns. 

How to make Iowa vs. Purdue picks

SportsLine's model is leaning under on the total, and it has also generated an against-the-spread pick that hits in almost 70 percent of simulations. You can only get the pick at SportsLine.

So who wins Iowa vs. Purdue? And which side of the spread hits almost 70 percent of the time? Visit SportsLine now to see which side of the Purdue vs. Iowa spread to jump on Saturday, all from the advanced model that is up over $4,000 on its top-rated college football spread picks, and find out.