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The Iowa State Cyclones and the Kansas State Wildcats will face off in a Big 12 clash at 7:30 p.m. ET on Oct. 16 at Bill Snyder Family Stadium. Both teams are 3-2; K-State is 2-1 at home, while the Cyclones are 1-1 on the road.  Iowa State demolished Kansas 59-7 last week. Kansas State fell 37-31 to the Oklahoma Sooners two weeks ago.

Iowa State has not won an away game vs. the Wildcats in 17 years. The Cyclones are favored by 6.5 points in the latest Kansas State vs. Iowa State odds from Caesars Sportsbook, and the over-under is set at 50.5. Before entering any Iowa State vs. Kansas State picks, you'll want to see the college football predictions from the model at SportsLine

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of almost $3,800 for $100 players on its top-rated college football picks against the spread. It also enters Week 7 of the 2021 season on a 19-7 run on all top-rated college football side picks. Anyone who has followed it has seen HUGE returns. .

Now, the model has set its sights on Kansas State vs. Iowa State and just released its coveted picks and predictions. You can head to SportsLine to see its picks. Here are several college football odds and betting lines for Kansas State vs. Iowa State:

  • Kansas State vs. Iowa State spread: Kansas State +6.5
  • Kansas State vs. Iowa State over-under: 50.5 points
Featured Game | Kansas State Wildcats vs. Iowa State Cyclones

What you need to know about Kansas State

Skylar Thompson passed for three TDs and 320 yards on 41 attempts in the loss to Oklahoma. He played through a knee injury in the loss. Thompson had not played previously since the second game of the season. Deuce Vaughn had 10 receptions for 104 yards and a TD. 

Vaughn has rushed for just 73 yards in the past two games. Malik Knowles returned a kickoff 93 yards for a TD vs. Oklahoma. Kansas State allowed the Sooners to score on all six trips into the red zone. 

What you need to know about Iowa State

Brock Purdy passed for four TDs and 245 yards on 22 attempts in addition to picking up 37 yards on the ground against Kansas. All of his scoring passes came in the first quarter. The 28 first quarter points were a program record. Iowa State's 59 points scored were a school record vs. Kansas. 

Breece Hall rushed for 123 yards and two TDs on 17 attempts vs. Kansas. Xavier Hutchinson had seven catches for 96 yards and a TD. Iowa State leads the Big 12 in scoring defense, at 14.2 points per game. 

How to make Kansas State vs. Iowa State picks

The model has simulated Kansas State vs. Iowa State 10,000 times and the results are in. We can tell you that the model is leaning Under, and it's also generated a point-spread pick that is hitting in over 50 percent of simulations. You can only see the pick at SportsLine.

So who wins Kansas State vs. Iowa State? And which side of the spread hits more than 50 percent of the time? Visit SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college football picks, and find out.