The Syracuse Orange won three of their first five games in 2019, but things took a turn and they finished the season with five losses in seven contests. Their struggles have continued in 2020, as they've clinched a losing record for the sixth time in seven years. The Orange attempt to build up their pride and end a five-game losing streak when they visit the ACC-rival Louisville Cardinals on Friday. Kickoff from Cardinal Stadium is scheduled for 7 p.m. ET.

Syracuse (1-7, 1-6 ACC) endured four consecutive double-digit losses before being more competitive in its last outing, a 16-13 setback against Boston College on Nov. 7. Louisville (2-6, 1-6) looks to avoid a third straight defeat after falling 31-17 at Virginia on Saturday. The Cardinals are 19.5-point favorites in the latest Louisville vs. Syracuse odds from William Hill Sportsbook, while the over-under for total points scored is 54.5. Before making any Syracuse vs. Louisville picks, check out the college football predictions from the SportsLine Projection Model.

The model simulates every FBS college football game 10,000 times. Over the past four-plus years, the proprietary computer model has generated a stunning profit of almost $3,900 for $100 players on its top-rated college football picks against the spread. It is a sizzling 39-21 on top-rated picks through 11 weeks of the 2020 college football season, returning over $1,000 in profit already. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Louisville vs. Syracuse. You can visit SportsLine now to see the picks. Here are the college football odds from William Hill and trends for Syracuse vs. Louisville:

  • Louisville vs. Syracuse spread: Cardinals -19.5
  • Louisville vs. Syracuse over-under: 54.5 points
  • Louisville vs. Syracuse money line: Cardinals -1000, Orange +650
  • LOU: The Cardinals are 5-0 against the spread in their last five games following a contest in which they score fewer than 20 points
  • SYR: The Orange are 1-5 ATS in the last six meetings

Why Louisville can cover

Malik Cunningham threw for 161 yards against Virginia to increase his season total to 1,907, putting him 159 away from setting a new career high. The junior quarterback was even more effective versus the Cavaliers with his legs, running for a personal-best 197 yards - the third-highest single-game total by a signal-caller in school history. Cunningham has rushed for 417 yards this year and 1,396 in his career, placing him second on Louisville's all-time list among quarterbacks.

Cunningham failed to throw a touchdown pass for the first time this season on Saturday but ran for a pair of scores, marking the second time in 2020 he has accomplished that feat. He is just the seventh quarterback in school history to record more than one multi-TD performance on the ground. With leading rusher Javian Hawkins (822 yards, seven TDs) electing to forego the rest of the season and focus on the 2021 NFL Draft, junior Hassan Hall (undisclosed) is expected to be returning just in time.

Why Syracuse can cover

Sean Tucker leads the Orange in rushing with 414 yards after gaining 52 on 11 carries against Boston College. The freshman is averaging five yards per carry and has produced all three of Syracuse's rushing touchdowns this season. Tucker has posted a pair of 100-yard performances thus far, becoming just the third true freshman with multiple such efforts in school history.

Aaron Hackett is on the verge of making Syracuse history after making his ninth career touchdown catch in his last contest. The senior, who hauled in six scoring passes last season, is tied with Nick Provo for the most TD receptions by an Orange tight end. Syracuse's defense leads the nation in 2020 with 17 takeaways, with sophomore linebacker Mikel Jones - who tops the team with 56 tackles - making three of the Orange's nine interceptions.

How to make Louisville vs. Syracuse picks

SportsLine's model is leaning under on the total. In fact, it says neither team produces a rusher or receiver with 100 or more yards. It also has generated an against-the-spread pick that cashes in almost 70 percent of simulations. You can only get the pick at SportsLine

So who wins Syracuse vs. Louisville? And which side of the spread cashes in nearly 70 percent of simulations? Visit SportsLine now to see which side of the Louisville vs. Syracuse spread to jump on, all from the advanced model that is up almost $3,900 on its top-rated college football spread picks, and find out.