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No. 22 Auburn and LSU will meet Saturday night in the battle known as the "Tiger Bowl." Auburn got back in the win column last week after falling short on the road against Penn State in Week 3. LSU had a three-possession lead in the fourth quarter, but the Tigers narrowly escaped with a 28-25 victory against Mississippi State. Auburn opened up its quarterback competition this week between Bo Nix and former LSU quarterback T.J. Finley. Both could play on Saturday. 

Kickoff from Tiger Stadium is set for 9 p.m. ET. The latest LSU vs. Auburn odds from Caesars Sportsbook list LSU at -3, while the over-under for total points is set at 56. Before finalizing any LSU vs. Auburn picks, be sure to see the college football predictions and betting advice from SportsLine's proven model.

The model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of almost $3,300 for $100 players on its top-rated college football picks against the spread. After going a sizzling 9-3 in Week 4, it enters Week 5 of the 2021 season on an 81-61 run on all top-rated college football picks. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on LSU vs. Auburn and it just revealed its CFB picks and predictions. You can visit SportsLine now to see the model's CFB Week 5 picks. Now, here are the college football odds and betting lines for Auburn vs. LSU:

  • Auburn vs. LSU spread: LSU -3
  • Auburn vs. LSU over-under: 56 points
  • Auburn vs. LSU money line: Auburn +140, LSU -160
  • AUB: Over is 4-1 in Tigers last five games overall
  • LSU: Tigers are 5-1 ATS in their last six conference games

Why Auburn can cover

The Tigers' offense has found plenty of success during the first month of the season. Auburn is the No. 18 offense in the nation, averaging 484 total yards with 7.0 yards per play. The Tigers had two monster performances to kick off their 2021 campaign, scoring at least 60 points in back-to-back games against Akron and Alabama State.

Despite the questions at quarterback, Auburn has one of the top rushing attacks in the nation. The Tigers average 257 yards on the ground, which ranks eighth in the country. Auburn has a two-headed monster in the backfield with sophomore Tank Bigsby and freshman Jarquez Hunter. This duo combines for 196.2 yards per game on the ground. The Tigers will look to get the ball in these running backs' hands as much as possible on Saturday night. 

Why LSU can cover

Sophomore quarterback Max Johnson has thrown at least 280 yards in three of four games played. In a two-week span, Johnson threw for 652 yards with nine touchdowns and just two interceptions. Early in the third quarter against Mississippi State, Johnson connected with sophomore receiver Kayshon Boutte, who caught a pass over the middle of the field and took it the house for a 75-yard score.

Freshman Deion Smith flashed his big-play ability against Central Michigan. Smith hauled in a season-high five receptions for 135 yards and two touchdowns. The freshman receiver averaged a staggering 27 yards per reception. The LSU offense will look to push the ball down the field. 

How to make Auburn vs. LSU picks

SportsLine's model is leaning over on the total, projecting 63 combined points. It also has generated an against-the-spread pick that cashes in well over 50 percent of simulations. You can get the pick over at SportsLine.

So who wins LSU vs. Auburn? And which side of the spread hits well over 50 percent of the time? Visit SportsLine now to see which side of the Auburn vs. LSU spread to back, all from the advanced model that is up almost $3,300 on its top-rated college football spread picks, and find out.