LSU vs. Florida odds, line: Week 6 college football picks, predictions from proven model on 49-36 run

One of the biggest conference matchups of Week 6 college football action features two ranked teams with the added benefit of being SEC crossover rivals. No. 5 LSU will visit No. 22 Florida in a contest between two SEC squads that have pleasantly surprised this season, and the latest LSU vs. Florida odds say that it should be close. LSU is favored by 1.5 points, down a point from where the line opened, while the total has continued to drop from 47.5 all the way down to 44.5. Considering the quality of the two defenses, that should be the only unsurprising thing about this matchup. But before you make your LSU vs. Florida picks, be sure you see what the SportsLine advanced computer model has to say about this 3:30 p.m. ET matchup on CBS. 

The SportsLine Projection Model simulates every FBS game 10,000 times, and those who have followed it have seen massive returns. In the past three years, this proprietary computer model has generated a jaw-dropping $4,210 profit for $100 bettors.

The model has also been red-hot on its top-rated college football picks this season, nailing its last four in Week 5 to improve its record to 49-36 overall. That run included correctly calling the Under (69.5) and Penn State (+3.5) against the spread vs. Ohio State in the huge Week 5 showdown between the Buckeyes and Nittany Lions. Anyone who has followed it is way up.

Now, the model turns its attention to Florida vs. LSU and has simulated every play 10,000 times. We can tell you the model is favoring the under, saying it hits in 69 percent of the time. It also has a strong spread pick that hits in almost 55 percent of simulations. You can only see that one at SportsLine.

The model knows LSU has jumped into the 2018-19 College Football Playoff fray after upsetting Miami and Auburn in the first three weeks of the season. The Tigers are now 5-0 after their most recent victory over Ole Miss and have been riding a defense loaded with NFL-caliber talent that is giving up just 15 points per game.

SportsLine's model says that defense will give Florida major problems Saturday, with the simulations projecting two turnovers and two sacks. The model also projects Florida to be held under 100 yards rushing.

However, that's not to say that things will be easy against the Gators. They are on a roll since their loss to Kentucky with three wins and three covers in their last three weeks, including road SEC wins over Tennessee and Mississippi State. All of a sudden, they're a Georgia win over Kentucky and a win of their own against Georgia from being right back in the hunt for the SEC East title.

They've gotten there because of their own defense, with 15 sacks and 13 turnovers forced through five games. And the SportsLine model expects more of the same against LSU, with the Florida defense even more likely than LSU's to get to the three-sack threshold and the potential to force two turnovers of their own.

So which side of the LSU vs. Florida spread hits almost 55 percent of the time? Visit SportsLine now to see which side you need to be all over, all from the proven computer model that has returned over $4,000 for $100 bettors.

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