Lyles was 7-of-9 passing for 160 yards while running back Javon Williams Jr. went 1-of-2 passing for a 41-yard touchdown. Williams also caught a 73-yard touchdown pass, his lone reception of the day, and rushed for 63 yards on 13 carries and a touchdown.
Youngstown State took its only lead of the game on Colten McFadden's 31-yard field goal with 9:04 left in the first quarter. Williams had a 7-yard scoring run and Lyles threw a 53-yard touchdown to Landon Lenoir for a 14-3 lead before the end of the first. Romeir Elliott ran it in from 3-yards out before Lyles found Williams on the 73-yarder that made it 28-3. The Penguins scored their only touchdown when Nathan Mays connected with Ryan Emans on 22-yard pass with eight seconds before halftime.
Southern Illinois (3-4, 1-2) ended a three-game skid and Youngstown State (4-3, 0-3) dropped its third straight.
Copyright 2019 by STATS LLC and Associated Press. Any commercial use or distribution without the express written consent of STATS LLC and Associated Press is strictly prohibited.