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The Penn State Nittany Lions and the No. 12 Michigan State Spartans will face off in a Big Ten clash at 3:30 p.m. ET on Saturday at Spartan Stadium. MSU is 9-2 overall and 5-0 at home, while the Nittany Lions are 7-4 overall and 2-2 on the road. This is the 36th time the programs have gone head-to-head and they're deadlocked at 17-17-1 in the all-time series.

They've also split their last 10 meetings against the spread, but the Nittany Lions have covered in two of the last three. The latest Michigan State vs. Penn State odds from Caesars Sportsbook list the Nittany Lions as 1.5-point favorites and the over-under is set at 52. Before entering any Penn State vs. Michigan State picks, you'll want to see the college football predictions from the model at SportsLine.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of almost $3,700 for $100 players on its top-rated college football picks against the spread. It also enters Week 13 of the 2021 season on a 39-25 run on all top-rated college football side picks. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Michigan State vs. Penn State. You can head to SportsLine to see its picks. Here are several college football odds for Penn State vs. Michigan State:

  • Michigan State vs. Penn State spread: Penn State -1.5
  • Michigan State vs. Penn State over-under: 52 points

What you need to know about Michigan State

The Spartans took a serious blow against the Ohio State Buckeyes last week, falling 56-7. MSU was in a tough position by the half with the score already sitting at 49-0.

It was an uncharacteristic performance by the No. 12-ranked team in the nation as Kenneth Walker III was limited to just 25 yards on six carries while battling an ankle injury. That likely takes Walker out of serious contention to win the Heisman Trophy, but he's still had a monster year with 1,508 rushing yards and 18 total touchdowns, and he'll have to get back on track in another tough matchup.

What you need to know about Penn State

The Nittany Lions made easy work of the Rutgers Scarlet Knights last week and carried off a 28-0 win. Penn State QB Christian Veilleux was slinging it as he passed for three touchdowns and 235 yards on 24 attempts in addition to picking up 36 yards on the ground. Veilleux's 67-yard touchdown toss down the right side of the field to WR Malick Meiga in the third quarter made for one of the most memorable moments of the day.

However, with Sean Clifford (illness) returning to the starting lineup this week, Veilleux will be relegated to a backup role. Clifford has thrown for 2,799 yards and 17 touchdowns with six interceptions this season but at times the Penn State offense has been stagnant with him in the game. So will Clifford's return help or hurt Penn State in a huge matchup on Saturday?

How to make Michigan State vs. Penn State picks

The model is leaning under on the total, and it's also generated a point-spread pick that is hitting in well over 50 percent of simulations. You can only see the pick at SportsLine.

So who wins Penn State vs. Michigan State? And which side of the spread hits well over 50 percent of the time? Visit SportsLine now to see which side of the spread you need to be all over, all from the model that has crushed its college football picks, and find out.