The Michigan Wolverines will take on the Northern Illinois Huskies at noon ET on Saturday at Michigan Stadium. Michigan is 2-0 and has jumped into the AP Poll at No. 25 in the rankings, while NIU is 1-1. This will be the Wolverines' second game against a MAC opponent as they took care of business in Week 1, defeating Western Michigan 47-14.

The Wolverines are favored by 27.5 points in the latest Michigan vs. Northern Illinois odds from Caesars Sportsbook, and the over-under is set at 54. Before entering any Michigan vs. Northern Illinois picks, you'll want to see the college football predictions from the model at SportsLine.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of over $3,500 for $100 players on its top-rated college football picks against the spread. It also enters Week 3 of the 2021 season on a 67-50 run on all top-rated college football picks. Anyone who has followed it has seen huge returns. 

Now, the model has set its sights on Michigan vs. Northern Illinois. You can head to SportsLine to see its picks. Here are several college football odds for Northern Illinois vs. Michigan:

  • Michigan vs. Northern Illinois spread: Michigan -27.5
  • Michigan vs. Northern Illinois over-under: 54 points
Featured Game | Michigan Wolverines vs. Northern Illinois Huskies

What you need to know about Michigan

A well-balanced attack led the Wolverines over the Washington Huskies every single quarter on their way to victory on Saturday as Michigan blew past Washington 31-10. Michigan's RB Blake Corum was on fire, rushing for three TDs and 171 yards on 21 carries. One of the most memorable plays of the matchup was Corum's 67-yard touchdown rush in the second quarter to give Michigan a double-digit lead it wouldn't let go of.

The Wolverines rank fourth in FBS with 339 rushing yards per game and they're doing it on a 6.8-yard rushing average. The duo of Corum and Hassan Haskins is doing the heavy lifting as both players have at least 35 carries and 225 yards. Corum has done a little bit of everything for Michigan as he also leads the Big Ten in kick return yards and has one of Michigan's three receiving touchdowns.

What you need to know about Northern Illinois

Meanwhile, NIU came up short against the Wyoming Cowboys on Saturday, falling 50-43. NIU was down 42-22 at the end of the third quarter, which was just too much to recover from. The 50 points that the Huskies allowed is the most they've given up at home since allowing 55 to Cincinnati in 1995.

Northern Illinois had a bottom-10 scoring defense in all of FBS last season, so this year appears just to be a continuation. That's bad news as it faces a Michigan team that is more talented across the board than the Wyoming team that hung 50 on it last week. The Huskies will hope Harrison Waylee, the MAC's leading rusher, can generate yardage on the ground and allow Northern Illinois to at least win the time of possession battle.

How to make Michigan vs. Northern Illinois picks

The model has simulated Michigan vs. Northern Illinois 10,000 times and the results are in. It is leaning over on the total, and it's also generated a point-spread pick that hits in almost 60 percent of simulations. You can only see the pick at SportsLine.

So who wins Michigan vs. Northern Illinois? And which side of the spread hits in almost 60 percent of simulations? Visit SportsLine now to find out which side of the spread you need to jump on, all from the model that has crushed its college football picks, and find out.