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The Mississippi State Bulldogs will take on the Memphis Tigers at 4 p.m. ET on Saturday at Liberty Bowl Memorial. Both teams are off to 2-0 starts on the season and now they'll renew a regional rivalry that dates back to 1951. Mississippi State holds a 33-11 all-time edge having won 12 straight games against Memphis. However, this is the first time the two schools have met since 2011.

Mississippi State is coming off an outright win as 1.5-point underdogs against NC State, while Memphis failed to cover as 5.5-point favorites in a 55-50 win over Arkansas State. The Bulldogs are favored by three-points in the latest Mississippi State vs. Memphis odds from Caesars Sportsbook, and the over-under is set at 64. Before entering any Memphis vs. Mississippi State picks, you'll want to see the college football predictions from the model at SportsLine.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of over $3,500 for $100 players on its top-rated college football picks against the spread. It also enters Week 3 of the 2021 season on a 67-50 run on all top-rated college football picks. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Memphis vs. Mississippi State. You can head to SportsLine to see its picks. Here are several college football odds for Mississippi State vs. Memphis:

  • Mississippi State vs. Memphis spread: Mississippi State -3
  • Mississippi State vs. Memphis over-under: 64 points
Featured Game | Memphis Tigers vs. Mississippi State Bulldogs

What you need to know about Memphis

Even if it wasn't a dominant performance, Memphis beat the Arkansas State Red Wolves 55-50 last Saturday. Ryan Silverfield's offense has fired on all cylinders through two weeks. The Tigers are averaging 634.5 yards of total offense and 48.5 points per game with quarterback Seth Henigan and running back Brandon Thomas racking up huge numbers along the way.

Henigan has completed 63.1 percent of his passes for 682 yards and six touchdowns without throwing an interception, while Thomas has rushed for 338 yards and three scores while averaging a staggering 9.9 yards per carry. It's an offense that eats up yardage in chunks and the Mississippi State defense will have to be disciplined to slow the Tigers down.

What you need to know about Mississippi State

Meanwhile, MSU won 24-10 over the NC State Wolfpack last Saturday. Quarterback Will Rogers threw for two TDs and 294 yards in the victory and has now thrown for 664 yards and five touchdowns on the season. Rogers is completing 75.0 percent of his passes but is only averaging 6.9 yards per attempt.

With Rogers and Mike Leach still looking to dial in the offense, the Mississippi State defense stepped up in a big way last week. The Bulldogs limited the Wolfpack to just 34 rushing yards and also forced three critical turnovers. Cornerback Emmanuel Forbes had a big day with 11 tackles, 1.5 tackles for loss and a sack.

How to make Mississippi State vs. Memphis picks

The model has simulated Memphis vs. Mississippi State 10,000 times and the results are in. We can tell you that the model is leaning under and it's also generated a point-spread pick that is hitting in over 60 percent of simulations. You can only see the pick at SportsLine.

So who wins Memphis vs. Mississippi State? And which side of the spread is a must-back? Visit SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college football picks.