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The No. 15 Alabama Crimson Tide (5-2, 2-2) are set to host the No. 21 Missouri Tigers (6-1, 2-1) in a pivotal SEC showdown on Saturday at Bryant-Denny Stadium. The Tide are looking to bounce back from a tough 24-17 loss to Tennessee in the "Third Saturday in October" rivalry game last week. Missouri will be looking to win its third straight game after knocking off Auburn 21-17 last week. Quarterback Brady Cook (ankle) is listed as questionable for the Tigers, an upgrade from being doubtful earlier in the week. Alabama has ruled safety Keon Sabb and linebacker Cayden Jones out. 

Kickoff in Tuscaloosa is scheduled for 3:30 p.m. ET. This line has been on the move all week with Cook's status up in the air, and the Crimson Tide are now favored by 15.5 points in the latest Alabama vs. Missouri odds via SportsLine consensus, while the over/under is 51 points. Before making any Missouri vs. Alabama picks, you need to see the Week 9 college football predictions and betting advice from SportsLine's Jimmie Kaylor

Kaylor is an NFL, college football and DFS expert for SportsLine, who has covered the NFL and college football for close to a decade as a member of the Pro Football Writers of America. His background as a former college football All-American and NFL player gives him a unique perspective when building his fantasy lineups and locking in his betting picks. He has his finger on the pulse of the college football landscape and has been cashing in big on sports betting apps for the last two years. 

Kaylor has destroyed the sportsbooks in college football the last two seasons, netting a whopping 63.8 units while posting a 178-107-2 record since Week 1 of the 2023 season. All of his picks have been featured on his SportsLine expert page or in his weekly bylined articles. Anyone who followed his picks is way up.

Now, Kaylor has dialed in on Alabama vs. Missouri on Saturday and just revealed his college football picks and predictions. You can head to SportsLine now to see his picks. Here are the college football odds and college football betting lines for Missouri vs. Alabama:

  • Missouri vs. Alabama spread: Alabama -15.5
  • Missouri vs. Alabama over/under: 51 points 
  • Missouri vs. Alabama money line: Alabama -775, Missouri +526
  • Missouri vs. Alabama picks: See picks at SportsLine
  • Missouri vs. Alabama streaming: FuboTV (Try for free)

Why Alabama can cover

Alabama has dominated this series since Missouri joined the SEC. The Tide have won the last five matchups against Mizzou, with four coming during the Tigers' SEC era. All four Alabama wins since 2012 have come in blowout fashion. 

The Tide have one of the most dynamic offensive duos in the country in quarterback Jalen Milroe and wide receiver Ryan Williams. Milroe, a Heisman Trophy candidate, has thrown for 1,722 yards, 13 touchdowns and six interceptions, and he's rushed for 330 yards and 11 scores. Williams, a 17-year-old freshman, has 31 catches for 649 yards and seven touchdowns. See which team to pick here

Why Missouri can cover

Missouri is one of the best defensive teams in college football. The Tigers enter this matchup ranked ninth in the country in total yards allowed per game (273) and passing yards allowed per game (157.6), and 10th in points allowed per game (15.6). Alabama relies heavily on its passing attack, which plays into the strength of Missouri's defense.

Freshman Jahkai Lang leads the team in sacks (3.0) and spearheads one of the SEC's best pass rushes. The Tigers have uncertainty surrounding Cook's health, but backup Drew Pyne is experienced. Mizzou has two high-end wide receivers in Luther Burden III (37 catches, 447yards, 4 touchdowns) and Theo Wease Jr. (35 catches, 463 yards, one touchdown) who can help out either quarterback. See which team to pick here

How to make Missouri vs. Alabama picks

Kaylor has analyzed Alabama vs. Missouri from every angle and he's leaning Under on the point total. He has also discovered a critical X-factor that has him jumping all over one side of the spread. He's only sharing what it is, and which side to back, at SportsLine.

So who wins Missouri vs. Alabama in Tuscaloosa on Saturday, and what critical X-factor makes one side of the spread a must back? Visit SportsLine now to see which side of the spread to jump on, all from the expert who profited $6,380 for $100 college football bettors since Week 1 of the 2023 season, and find out.