North Carolina vs. Duke odds, line: 2022 college football picks, Week 7 predictions from proven computer model
SportsLine's model just revealed its college football picks for Duke Blue Devils vs. North Carolina Tar Heels

The North Carolina Tar Heels will have an opportunity to extend their two-game winning streak when they face the Duke Blue Devils on Saturday night. North Carolina pulled off an upset over Miami (FL) last week, picking up a 27-24 win as a 4-point underdog. Duke, meanwhile, is hoping to bounce back after losing to Georgia Tech as a 3.5-point favorite.
Kickoff is set for 8 p.m. ET. The Tar Heels are favored by 7 points in the latest Duke vs. North Carolina odds from Caesars Sportsbook, while the over/under is set at 67. Before entering any North Carolina vs. Duke picks, you'll want to see the college football predictions from the advanced computer model at SportsLine.
The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past six-plus years, the proprietary computer model has generated a stunning profit of almost $3,000 for $100 players on its top-rated college football picks against the spread. Anyone who has followed it has seen huge returns.
Now, the model has set its sights on Duke vs. North Carolina. You can head to SportsLine to see its picks. Here are several college football odds for Duke vs. North Carolina:
- Duke vs. North Carolina spread: Duke +7
- Duke vs. North Carolina over/under: 67 points
- Duke vs. North Carolina picks: See picks here
Why Duke can cover
Duke has been a different team at home this season, as its two losses have both come on the road in one-possession games. The Blue Devils are 3-0 at home, winning all three of those games by at least 19 points. They are coming off a loss to Georgia Tech in overtime last week, but they scored two touchdowns in the final six minutes to get the game to an extra period in the first place.
Sophomore quarterback Riley Leonard has thrown for 1,312 yards and eight touchdowns, while junior running back Jaylen Coleman has rushed for 307 yards and four scores. Leonard has the third-best completion percentage in the ACC (65.9) and is facing a North Carolina defense that gave up 45 points to Notre Dame and 61 points to Appalachian State. Duke is having an above-average season and its fan base will be excited for this matchup against an in-state rival.
Why North Carolina can cover
North Carolina has been an excellent team this season, with its lone loss coming against Notre Dame. The Tar Heels have responded from that setback with a 31-point win over Virginia Tech and a 27-24 win at Miami (FL). They were 4-point underdogs in the win over the Hurricanes and have now covered the spread in four of their last five conference games.
The Tar Heels have also been dominant in this series, winning 10 of their last 13 road games at Duke. Quarterback Drake Maye ranks second in the ACC in completion percentage, sitting nearly four percentage points ahead of Leonard. North Carolina has been improved defensively over the past few weeks, holding Virginia Tech to 10 points and Miami to 42 rushing yards.
How to make Duke vs. North Carolina picks
The model has simulated North Carolina vs. Duke 10,000 times and the results are in. We can tell you that the model is leaning Over, and it's also generated a point-spread pick that is hitting in almost 60% of simulations. You can only see the pick at SportsLine.
So who wins Duke vs. North Carolina? And which side of the spread hits in almost 60% of simulations? Visit SportsLine now to see which side of the North Carolina vs. Duke spread you need to jump on Saturday, all from the model that has crushed its college football picks, and find out.















