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A Big Ten battle is on tap Saturday between the Michigan State Spartans and the 11th-ranked Northwestern Wildcats at 3:30 p.m. ET at Spartan Stadium. MSU is 1-3 overall and 0-2 at home, while Northwestern is 5-0 overall and 2-0 on the road. The Wildcats are 5-0-1 against the spread in their last six games. The Spartans are 2-6 against the spread in their last eight games following a bye week.

The Wildcats are favored by 13-points in the latest Michigan State vs. Northwestern odds from William Hill Sportsbook, and the over-under is set at 41.5. Before you make any Northwestern vs. Michigan State picks, check out the college football predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past four-plus years, the proprietary computer model has generated a stunning profit of over $3,600 for $100 players on its top-rated college football picks against the spread. It is also a sizzling 44-23 on all top-rated picks through 12 weeks of the 2020 college football season, returning over $1,200 in profit already. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Northwestern vs. Michigan State. You can visit SportsLine now to see the picks. Here are the college football odds and trends for Michigan State vs. Northwestern:

  • Northwestern vs. Michigan State spread: Wildcats -13
  • Northwestern vs. Michigan State over-under: 41.5 points
  • Northwestern vs. Michigan State money line: Wildcats -550, Spartans +400

What you need to know about Northwestern

The Wildcats are coming off a monumental victory over then-No. 10 Wisconsin last week, propelling Northwestern to the top of the Big Ten West Division and into the College Football Playoff discussion. Graduate transfer QB Peyton Ramsey is completing 62 percent of his passes and has thrown eight touchdowns this season. 

Northwestern's defense gives up only 100.6 rushing yards and 12.6 points per game, both are second in the Big Ten. And the Wildcats have won four straight close games since a 43-3 blowout of Maryland in the opener -- recording an average margin of victory of just 6.5 points. 

What you need to know about Michigan State

The Spartans have only beaten Michigan this season, a three-point Halloween victory over the then-No. 13 team in the country. Since then, though, Michigan State has been blown out by Iowa and Indiana -- and had last week's winnable game against Maryland cancelled due to a COVID-19 outbreak in College Park.

Coach Mel Tucker maintained that the starting quarterback spot has been open all week, mainly between Rocky Lombardi and Payton Thorne. Lombardi has started all four games, but was benched midway through the second quarter against the Hoosiers two weeks ago for Thorne -- who finished 10-of-20 for 110 yards.

How to make Northwestern vs. Michigan State picks

SportsLine's model is leaning under on the total. In fact, it says both teams will combine for just 31 points. It has also generated an against-the-spread pick that cashes in almost 70 percent of simulations. You can only get the pick at SportsLine

So who wins Michigan State vs. Northwestern? And which side of the spread cashes in almost 70 percent of simulations? Visit SportsLine now to see which side of the Michigan State vs. Northwestern spread to jump on, all from the advanced model that is up over $3,600 on its top-rated college football spread picks, and find out.