The Louisville Cardinals travel to South Bend to take on the No. 4 Notre Dame Fighting Irish on Saturday afternoon. Louisville will look to right the ship after a 1-3 start, even against a talented opponent. Notre Dame will aim to build on a 3-0 record, including a win over Florida State last week, and a top-five national ranking. Kickoff is at 2:30 p.m. ET in South Bend. 

The latest Notre Dame vs. Louisville odds from William Hill list the Irish as 16.5-point favorites, up two points from the opening line. The over-under for total points is 61, down from opening at 64. Before making any Louisville vs. Notre Dame picks, check out the college football predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past four-plus years, the proprietary computer model has generated a stunning profit of over $4,200 for $100 players on its top-rated college football picks against the spread. It is a sizzling 23-6 on top-rated picks through six weeks of the 2020 college football season, returning almost $1,300 in profit already. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Notre Dame vs. Louisville. You can visit SportsLine now to see the picks. Here are the college football odds from William Hill and trends for Louisville vs. Notre Dame:

  • Notre Dame vs. Louisville spread: Notre Dame -16.5
  • Notre Dame vs. Louisville over-under: 61 points
  • Notre Dame vs. Louisville money line: Notre Dame -700, Louisville +500
  • ND: The Fighting Irish are 1-2 against the spread this season
  • LOU: The Cardinals are 1-3 against the spread in the last four games

Why Notre Dame can cover

The Notre Dame offense is both efficient and productive, doing more than enough to complement an elite defense. The Irish rank in the top 15 nationally in total offense, averaging 475 yards per game, and that mark is good for fourth in the ACC. Notre Dame also ranks third in the conference in scoring, averaging 40.3 points per game, and the Irish are balanced in their approach. Ian Book headlines a passing offense that is averaging 8.0 yards per attempt, ranking in the top five of the ACC, and Notre Dame also ranks fourth in completion percentage at 62.3 percent. 

Given that Louisville ties for last place in the ACC with nine touchdown passes allowed and ranks second-worst in the league in allowing 8.2 yards per attempt, Notre Dame's air attack sets up as a strength. Elsewhere, Notre Dame is a tremendous rushing offense, ranking in the top nationally at 270.7 yards per game on the ground. The Irish lead the ACC with 12 rushing touchdowns, and they are bludgeoning opposing defenses to the tune of 6.3 yards per carry.

Why Louisville can cover

Louisville is in need of a win after three consecutive defeats, but the Cardinals do have a few areas to be excited about in this matchup. Louisville is an above-average offensive team, averaging 424.3 yards per game this season, and that includes an impressive 177.8 rushing yards per game. Quarterback Micale Cunningham has accounted for more than 1,000 total yards and 12 touchdowns this season, with Tutu Atwell operating as one of the best slot receivers in the nation. Atwell already has 25 catches for 281 yards and four touchdowns, and Louisville is tied for fifth in the ACC in averaging 8.0 yards per pass attempt. 

Cunningham also leads a passing offense that ranks in a tie for second in the league with nine touchdowns through the air. Defensively, Louisville will have its hands full with Notre Dame's ground attack, but there is reason to believe it can hold up in the secondary. The Cardinals ranks as a top-five passing defense in the ACC this season, giving up only 233 yards per game.

How to make Notre Dame vs. Louisville picks

SportsLine's model is leaning over on the total, with Louisville's Javian Hawkins projected to rush for 100 yards with Book projected for more than three touchdown passes. The model also says one side of the spread hits in over 60 percent of simulations. Head to SportsLine to see the pick

So who wins Louisville vs. Notre Dame? And which side of the spread hits in over 60 percent of simulations? Visit SportsLine now to find out which side of the Notre Dame vs. Louisville spread you need to jump on Saturday, all from the model that has crushed its college football picks, and find out.