No. 10 Notre Dame (5-1) will face a ranked opponent for the third week in a row when it plays at No. 25 Louisville (5-0) on Saturday night. The Fighting Irish bounced back from their heartbreaking loss to then-No. 6 Ohio State with a 21-14 win at then-No. 17 Duke last week. Louisville remained unbeaten with its 13-10 win at NC State last week, but this will be its first ranked opponent of the year. The Cardinals came up short in a 12-7 final the last time they faced Notre Dame, which was in October of 2020.
Kickoff is set for 7:30 p.m. ET on Saturday at L&N Federal Credit Union Stadium in Louisville. The Fighting Irish are favored by 6.5 points in the latest Louisville vs. Notre Dame odds, while the over/under is set at 53.5 points, per SportsLine consensus. Before making any Louisville vs. Notre Dame picks or bets, be sure to check out the college football predictions and betting advice from SportsLine football expert Jimmie Kaylor.
Kaylor is a NFL, college football and DFS expert for SportsLine, who has covered the NFL and college football for close to a decade as a member of the Pro Football Writers of America. His background as a former college football All-American and NFL player gives him a unique perspective when building his fantasy lineups and locking in his betting picks.
Kaylor has been red-hot on his football picks for SportsLine, going 9-1 last week and 4-0 in the Notre Dame vs. Duke game, bringing his season record to 18-3 on his best bets in 2023. Anyone who has followed his picks is way up.
Now, he has set his sights on Notre Dame vs. Louisville and just locked in its picks and CFB predictions. You can head to SportsLine now to see Kaylor's picks. Here are several college football odds and betting lines for Notre Dame vs. Louisville:
- Notre Dame vs. Louisville spread: Notre Dame -6.5
- Notre Dame vs. Louisville over/under: 53.5 points
- Notre Dame vs. Louisville money line: Notre Dame -256, Louisville +207
- ND: QB Sam Hartman has 14 TD passes in 2023.
- LOU: Louisville averages 494.8 total yards of offense per game.
- Notre Dame vs. Louisville picks: See picks at SportsLine
- Notre Dame vs. Louisville live stream: fubo (try for free)
Why Notre Dame can cover
Notre Dame was able to keep its College Football Playoff hopes alive with last week's win at Duke, putting together a late rally after blowing a 13-0 lead. Hartman did not score a touchdown for the first time this season, but he engineered a 95-yard game-winning drive that was capped off by a 30-yard scoring run by Audric Estime. Notre Dame improved to 5-2 in its last seven games against nationally ranked opponents, so the Fighting Irish will not be intimidated on Saturday night.
Louisville was fortunate to beat NC State after falling into a 10-0 hole in the first half, as its defense held the Wolfpack to 72 yards after halftime. The Cardinals have relied heavily on their defense to win games, but they are facing a much stronger offense this week. Notre Dame has covered the spread at an 8-1 clip in its last nine road games, and it has covered in 10 consecutive games against ACC opponents. See which team to pick at SportsLine.
Why Louisville can cover
The Cardinals are a confident group under first-year head coach Jeff Brohm. They enter this matchup with a perfect record and have made their first appearance since 2020 in the top-25 of the national coaches poll. A win will give the Cardinals their first 6-0 start since the 2013 season.
Louisville has one of the most dynamic players in the ACC in running back Jawhar Jordan. The former Syracuse transfer is a true home run threat out of the backfield and enters this game averaging 7.7 yards per carry. For the season, he has 510 rushing yards and six TDs, and seven receptions for 159 yards and a receiving TD. See which team to back at SportsLine.
How to make Louisville vs. Notre Dame picks
Kaylor has analyzed this matchup from every angle and he's leaning Under on the point total. He has also discovered a critical X-factor that has him jumping all over one side of the spread. He's only sharing what it is, and which side to back, at SportsLine.
Who wins Notre Dame vs. Louisville on Saturday, and which critical X-factor makes one side of the spread a must-back? Visit SportsLine now to see Notre Dame vs. Louisville picks, all from the expert who has covered college football for over a decade and is 18-3 on his best bets in 2023, and find out.
