Heading into the final week of college football's regular season, one-loss Notre Dame finds itself on the outside looking in at the top four teams in the College Football Playoff rankings. That spells trouble for hapless Stanford, which has lost six games in a row, and could easily find itself on the receiving end of a beatdown in the quest for style points by the Fighting Irish. Stanford has given up 128 points over its last three games, and hosts Notre Dame on Saturday, Nov. 27 at 8 p.m. ET.
The Fighting Irish are favored by 19 points in the latest Stanford vs. Notre Dame odds from Caesars Sportsbook, and the over-under is set at 52.5. Before making any Notre Dame vs. Stanford picks, be sure to check out the college football predictions and betting advice from the red-hot simulation model at SportsLine.
The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of almost $3,700 for $100 players on its top-rated college football picks against the spread. It also enters Week 13 of the 2021 season on a 39-25 run on all top-rated college football side picks. Anyone who has followed it has seen huge returns.
Now, the model has set its sights on Stanford vs. Notre Dame and just locked in its CFB picks and predictions. You can head to SportsLine now to see the model's picks. Here are several college football odds and betting lines for Stanford vs. Notre Dame:
- Stanford vs. Notre Dame spread: Notre Dame -19
- Stanford vs. Notre Dame over-under: 52.5 points
- Stanford vs. Notre Dame money line: ND -1000, STAN +650
What you need to know about Notre Dame
Notre Dame kept a clean sheet against the Georgia Tech Yellow Jackets on Saturday and took the game 55-0. In the Fighting Irish's two games before that, against Navy and Virginia, they gave up just nine total points. Notre Dame also heads into its final regular season game with one of the nation's top scoring defenses, and has given up just 18.6 points per game.
Running back Kyren Williams is just 69 yards shy of 1,000 for the season, and he had 56 yards on an easy day at the office last weekend, with just 11 carries and two rushing touchdowns. Williams also had the most receptions of any Irish player, with four catches that resulted in 31 yards. Quarterback Jack Coan may not be the most dynamic player in college football, but he's been an efficient passer for the Irish. The grad transfer from Wisconsin has completed 66.8 of his passes this season and has 17 touchdowns to just four interceptions.
What you need to know about Stanford
What more can be said about Stanford's fall from grace this season after knocking off Oregon earlier in the year? The Cardinal's most recent game was another disaster, as Cal won easily, 41-11 on Saturday. Stanford was down 27-3 at the end of the third quarter, which was just too much to recover from. Quarterback Tanner McKee threw two interceptions in an otherwise unremarkable game.
Stanford has failed to score more than two touchdowns in any of its last four games, and hasn't come up with more than 247 yards of offense in its last three. Against Utah on November 5, the Cardinal generated just 167 yards. E.J. Smith, son of Hall of Fame running back Emmitt Smith, has been getting reps on offense, but hasn't been able to get much going for struggling Stanford. His best collegiate game to date came in the loss to Utah, when he had seven carries for 53 yards, and represented 37 percent of Stanford's total offensive output.
How to make Stanford vs. Notre Dame picks
The model has simulated Stanford vs. Notre Dame 10,000 times and the results are in. We can tell you that the model is leaning Over on the point total, and it's also generated a point-spread pick that is hitting in nearly 60 percent of simulations. You can only see the model's Notre Dame vs. Stanford pick at SportsLine.
Who wins Stanford vs. Notre Dame? And which side of the spread hits in almost 60 percent of simulations? Visit SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college football picks, and find out.









