The Ohio State Buckeyes take on the Akron Zips at 7:30 p.m. ET on Saturday at Ohio Stadium. The Buckeyes announced on Thursday that starting quarterback C.J. Stroud will not play in the game to rest a sore shoulder. The Zips hope that opens the door for for them to make things interesting against one of the country's top programs.

Without Stroud in the lineup for Ohio State, head coach Ryan Day said that he plans to give both Kyle McCord and Jack Miller reps at quarterback in the game. The last time these two teams played was in 2011, when the Buckeyes dismantled Akron, 42-0. The Ohio State is favored by 49 points in the latest Ohio State vs. Akron odds from Caesars Sportsbook, and the over-under is set at 67.5. Before entering any Akron vs. Ohio State picks, you'll want to check out the college football predictions and analysis from the model at SportsLine.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of almost $3,000 for $100 players on its top-rated college football picks against the spread. It also enters Week 4 of the 2021 season on a 72-58 run on all top-rated college football picks. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Ohio State vs. Akron and just revealed its picks and predictions. You can head to SportsLine to see the model's picks. Here are several college football odds and betting lines for Ohio State vs. Akron:

  • Ohio State vs. Akron spread: Ohio State -49
  • Ohio State vs. Akron over-under: 68 points
  • OSU: 10-0 overall and 5-5 against the spread as home favorite by at least 35 points
  • AKR: 2-8 overall and 3-7 ATS in last 10 games

What you need to know about Ohio State

Neither McCord or Miller have thrown a pass for the Buckeyes, but McCord was a five-star prospect coming out of high school and Miller was a high four-star. Regardless of who is taking the snaps, the running game should carry the day for Ohio State anyway. TreVeyon Henderson has 346 yards rushing already and one of the country's highest yards per carry averages at 9.11. Last week against Tulsa, he ripped off a 52-yard touchdown run in the third quarter.

Backing up Henderson is Miyan Williams, who has an 8.8 yards per carry average of his own and 202 rushing yards on the season. Ohio State still hasn't plugged all the leaks in its defense from the past few seasons, and has allowed more than 181 rushing yards per game in 2021, but won't sweat things too much against the Zips. Akron's offensive line has already allowed 12 sacks this season, so Ohio State's defensive front should run wild.

What you need to know about Akron

To the extent that Akron finds offensive success, it all begins and ends with quarterback Demarcus Irons Jr. The sophomore has been an effective passer, and has completed over 75-percent of his throws with five touchdowns to just one interception. He is also the Zips' leading rusher, and has 165 yards on the ground this season with another two scores.

Michael Mathison has been the top option in the passing game for Akron, and he has 18 catches for 230 yards in 2021. If Akron can't manage to keep things close, Ohio State should be able to run away from the Zips pretty easily. Akron's defense has surrendered 174 yards per game on the ground, and opposing quarterbacks have completed 77-percent of their passes against them this season.

How to make Akron vs. Ohio State picks

The model has simulated Ohio State vs. Akron 10,000 times and the results are in. We can tell you that the model is leaning over on the point total, and it's also generated a point-spread pick that is hitting in almost 60 percent of simulations. You can only see the model's Ohio State vs. Akron pick at SportsLine.

So who wins Ohio State vs. Akron? And which side of the spread is hitting in almost 60 percent of simulations? Visit SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college football picks, and find out.