The No. 9 Indiana Hoosiers travel to Columbus to take on the No. 3 Ohio State Buckeyes on Saturday afternoon. The matchup features the co-leaders in the Big Ten East, with Indiana entering at 4-0 and Ohio State sitting at 3-0 on the season. Indiana toppled Michigan and Michigan State in back-to-back weeks, catapulting into the top 10 nationally. Ohio State began the season as the conference favorite and has three victories by double-digits in 2020. 

Kickoff is at noon ET. William Hill Sportsbook lists the Buckeyes as 20.5-point favorites in the latest Ohio State vs. Indiana odds, up one point from the opening line. The over-under for total points expected is set at 66. Before making any Indiana vs. Ohio State picks, check out the college football predictions from the SportsLine Projection Model.

The model simulates every FBS college football game 10,000 times. Over the past four-plus years, the proprietary computer model has generated a stunning profit of almost $3,900 for $100 players on its top-rated college football picks against the spread. It is a sizzling 39-21 on top-rated picks through 11 weeks of the 2020 college football season, returning over $1,000 in profit already. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Ohio State vs. Indiana. You can visit SportsLine now to see the picks. Here are the college football odds from William Hill and trends for Indiana vs. Ohio State:

  • Ohio State vs. Indiana spread: Ohio State -20.5
  • Ohio State vs. Indiana over-under: 66 points
  • Ohio State vs. Indiana money line: Ohio State -1100, Indiana +700
  • OSU: The Buckeyes are 11-6 against the spread since the start of 2019
  • IND: The Hoosiers are 12-5 against the spread since the start of 2019

Why Ohio State can cover

Ohio State is one of the best offensive teams in the country, and that is evident with the team's statistical profile. The Buckeyes currently rank fourth in the nation in scoring offense, averaging 46.3 points per game, and Ohio State ranks at or near the top of the Big Ten in several important categories. Ryan Day's team leads the conference in total offense, putting up 511.3 yards per game, and the Buckeyes rank second in passing offense (302.7 yards per game) and third in rushing offense (208.7 yards per game). 

With Heisman Trophy candidate Justin Fields at the helm, Ohio State is also elite on third down, converting 58.1 percent of its chances, and the Buckeyes are extremely difficult to stop. Defensively, Ohio State is also loaded with five-star talent, with the Buckeyes ranking in the top five of the Big Ten in allowing just 356.0 yards per game.

Why Indiana can cover

Indiana has a balanced attack that includes a top-four defense in the Big Ten this season. In addition, the Hoosiers are also enjoying plenty of success on the offensive side of the ball. Quarterback Michael Penix Jr. leads the Big Ten with 1,070 passing yards, and he trails only Fields with nine touchdown passes. Penix Jr. can take solace in having an elite pass-catcher in Ty Fryfogle, as the wide receiver leads the Big Ten in receiving yards (424) while landing second in touchdown catches (four). 

On the ground, Stevie Scott III is tied for second in the Big Ten with five rushing touchdowns, and he also ranks fourth in the conference with 319 rushing yards. Ohio State's defense isn't quite as good as its offense, and Indiana will need to score in bunches to keep up with the Buckeyes. 

How to make Ohio State vs. Indiana picks

SportsLine's model is leaning under on the total, with neither team projected to have a 75-yard rusher. The model also says one side of the spread hits in over 60 percent of simulations. You can only get the pick at SportsLine

So who wins Indiana vs. Ohio State? And which side of the spread cashes in over 60 percent of simulations? Visit SportsLine now to see which side of the Ohio State vs. Indiana spread to jump on, all from the advanced model that is up almost $3,900 on its top-rated college football spread picks, and find out.