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A Big Ten battle is on tap between the Ohio State Buckeyes and the Indiana Hoosiers at 7:30 p.m. ET on Saturday at Memorial Stadium. IU is 2-4 overall and 1-2 at home, while OSU is 5-1 overall and 2-0 on the road. Ohio State is 3-2-1 against the spread and Indiana is 1-5 ATS in 2021.

The Buckeyes are favored by 19 points in the latest Indiana vs. Ohio State odds from Caesars Sportsbook, and the over-under is set at 60. Before making any Ohio State vs. Indiana picks or CFB predictions, you need to see the college football predictions and betting advice from the proven computer simulation model at SportsLine.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of almost $3,700 for $100 players on its top-rated college football picks against the spread. It also enters Week 8 of the 2021 season on a 22-9 run on all top-rated college football side picks. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Indiana vs. Ohio State and just locked in its picks and predictions. You can head to SportsLine now to see the model's CFB picks. Now, here are several college football odds and betting lines for Indiana vs. Ohio State:

  • Indiana vs. Ohio State spread: Indiana +19
  • Indiana vs. Ohio State over-under: 60 points
Featured Game | Indiana Hoosiers vs. Ohio State Buckeyes

What you need to know about Ohio State

You're bound to get a positive result if you outscore your opponent every quarter, and that's exactly how it played out for the Buckeyes last week. They were fully in charge, breezing past the Maryland Terrapins 66-17 at home. The contest was pretty much decided by the half, when the score had already reached 35-10. OSU quarterback C.J. Stroud was outstanding, passing for 406 yards and five touchdowns. 

Stroud has taken his game to another level in the Buckeyes' last two contests, throwing for a whopping 736 yards and 10 touchdowns. Stroud's top two targets are Chris Olave and Garrett Wilson, who have combined for 61 catches for 1,040 yards and 13 touchdowns in 2021.

What you need to know about Indiana

There was early excitement for Indiana after they claimed the game's first points on Saturday, but it was the Michigan State Spartans who ended up claiming the real prize. IU was within a late touchdown of stealing the win, but they ultimately took the loss against MSU by a score of 20-15. Quarterback Jack Tuttle had a memorable game, but not in the way you want to be remembered. Aside from failing to produce a single touchdown, he threw two interceptions and fumbled the ball away once while filling in for the injured Michael Penix Jr

The Hoosiers 2-4 overall record isn't pretty, but three of their four losses have come against teams ranked in the top-10 nationally. Indiana wide receiver Ty Fryfogle is dynamic and could give the Ohio State secondary fits. 

How to make Ohio State vs. Indiana picks

The model has simulated Indiana vs. Ohio State 10,000 times and the results are in. We can tell you that the model is leaning under on the point total, and it's also generated a point-spread pick that is hitting in over 60 percent of simulations. You can only see the model's Ohio State vs. Indiana pick at SportsLine.

So who wins Indiana vs. Ohio State? And which side of the spread hits in well over 60 percent of simulations? Visit SportsLine now to see which side of the point spread to back, all from the model that has crushed its college football picks, and find out.