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The No. 3 Ohio State Buckeyes will look to keep their undefeated record intact when they host the Iowa Hawkeyes for a Big Ten battle on CBS and Paramount+. The Buckeyes enter Saturday's showdown averaging 48.8 points per game, which ranks fourth in the nation. Iowa has been stout defensively, giving up just 13.75 points per game, which ranks 15th in college football.

Kickoff from Ohio Stadium is set for 3:30 p.m. ET. After opening at -18.5, the Buckeyes are now 17.5-point favorites in the latest Ohio State vs. Iowa odds via SportsLine consensus, while the over/under for total points scored is 46.5, up from opening at 42.5. Before making any Iowa vs. Ohio State picks, be sure to check out the college football predictions and betting advice from the SportsLine Projection Model.

Saturday's game can be seen live on CBS and streamed live on Paramount+, which you can now get for a 7-day free trial. Sign up right here.

The model simulates every FBS college football game 10,000 times. Since its inception, it has generated a profit of well over $2,000 for $100 players on its top-rated college football picks against the spread. It also went a sizzling 6-0 on all top-rated college football picks in Week 5. Anyone who has followed it has seen strong returns.

Now, the model has dialed in on Ohio State vs. Iowa and just revealed its coveted picks and predictions. You can head to SportsLine now to see the model's picks. Here are the college football odds for the spreadmoney line and over/under:

  • Ohio State vs. Iowa spread: Ohio State -17.5
  • Ohio State vs. Iowa over/under: 46.5 points 
  • Ohio State vs. Iowa money line: Ohio State -1205, Iowa +727
  • Ohio State vs. Iowa picks: See picks at SportsLine
  • Ohio State vs. Iowa streaming: Paramount+ (Get seven days free)

Why Ohio State can cover

The Buckeyes enter Saturday's showdown with college football's best scoring defense. Ohio State is giving up just 6.8 points per game this season, the lowest in the nation. The Buckeyes gave up only 47 rushing yards in last week's victory over Michigan State while forcing three turnovers against the Spartans. Ohio State's defensive front is giving up 61.8 rushing yards per game, which ranks third in the nation.

Offensively, the Buckeyes feature a plethora of playmakers. Quarterback Will Howard is competing 68.6% of his passes for 1,039 yards and eight touchdowns this season. He's also scored three rushing touchdowns in 2024. Running back TreVeyon Henderson is averaging a whopping 8.9 yards per carry, while wide receiver Jeremiah Smith has hauled in 19 receptions for 364 yards and five TDs. See picks at SportsLine.

Why Iowa can cover

The Hawkeyes have found some rhythm offensively after suffering a 20-19 setback against Iowa State earlier this season. Iowa has scored 31 or more points in each of its last two games behind an effective rushing attack. In last week's victory over Minnesota, running back Kaleb Johnson recorded 21 carries for 206 yards and three touchdowns. 

For the season, Johnson has racked up 685 rushing yards and nine rushing touchdowns. He's scored at least two rushing touchdowns in every game this season and he'll likely be heavily featured in Iowa's offensive game plan on Saturday. Defensively, the Hawkeyes are giving up only 62.0 rushing yards per game. See picks at SportsLine.

How to make Iowa vs. Ohio State picks

SportsLine's model is leaning Under on the total, projecting 46 combined points. It also says one side of the spread hits in well over 50% of simulations. You can see the model's pick at SportsLine.

So who wins Ohio State vs. Iowa, and which side of the spread hits well over 50% of the time? Visit SportsLine now to see which side of the spread to jump on, all from the advanced model that is up well over $2,000 on top-rated spread picks since its inception, and find out, and don't forget to stream Iowa vs. Ohio State on Paramount+.