Oklahoma vs. Iowa State: Prediction, pick, odds, line, TV channel, live stream, watch online
The Sooners go on the road for the first time this season hoping to avenge last year's loss
That's when the Cyclones went on the road and shocked the then-No. 3 Sooners, 38-31. While the loss didn't keep Oklahoma out of the College Football Playoff, it did mark the arrival of Iowa State to the Big 12 title race -- at least for a while.
One year later, Oklahoma is once again a heavy favorite over Iowa State, but do the Cyclones have the same offensive firepower to keep up? Here's what you need to know about picking Saturday's early kickoff.
Date: Saturday, Sept. 15 | Time: Noon ET
Location: Jack Trice Stadium -- Ames, Iowa
TV: ABC | Live stream: WatchESPN
Oklahoma: Rodney Anderson is (and may have played his final game in a Sooners uniform). So how does the running game respond? It will likely be a committee approach with Trey Sermon, T.J. Pledger and Marcelias Sutton getting an increased number of carries, along with quarterback Kyler Murray seeing his share of carries. Sermon had some big games last season before Anderson emerged. The good news is the backfield depth is more than adequate. So, who emerges?
Iowa State: Running back David Montgomery is a stud, but he rushed for just 44 yards at about 2.6 yards per attempt against Iowa. That's less on Montgomery and more on the lack of available threats around him. Quarterback Kyle Kempt has a knee injury that may prevent him from playing, too (Zeb Noland would get the start in that case). Can the Cyclones' offense open up at all? Because right now it's in a tough place with a likely shootout necessary.
Game prediction, picks
An early kickoff in Ames has "catch Oklahoma napping" potential, but the early evidence strongly suggests the visiting Sooners can handle this game. They've handled business against FAU and UCLA already. You have to score a lot of points to beat Oklahoma, so can the Cyclones get into the 30s, at least? Otherwise, Oklahoma might run away with another one. Pick: Oklahoma -18.5
What college football picks can you make with confidence in Week 3? And what team delivers a massive upset? Visit SportsLine to see which teams are winning more than 50 percent of simulations, all from a proven computer model on an 11-2 run that has returned over $4,000 in profit over the past three seasons.
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