Oklahoma vs. Iowa State: Prediction, pick, odds, line, TV channel, live stream, watch online

No. 5 Oklahoma and Iowa State will meet in a Big 12 opener for both teams that will surely conjure memories of one of the biggest upsets of the 2017 season.

That's when the Cyclones went on the road and shocked the then-No. 3 Sooners, 38-31. While the loss didn't keep Oklahoma out of the College Football Playoff, it did mark the arrival of Iowa State to the Big 12 title race -- at least for a while. 

One year later, Oklahoma is once again a heavy favorite over Iowa State, but do the Cyclones have the same offensive firepower to keep up? Here's what you need to know about picking Saturday's early kickoff. 

Viewing information

Date: Saturday, Sept. 15 | Time: Noon ET
Location: Jack Trice Stadium -- Ames, Iowa
TV:
ABC | Live stream: WatchESPN

Storylines

Oklahoma: Rodney Anderson is once again out for the season (and may have played his final game in a Sooners uniform). So how does the running game respond? It will likely be a committee approach with Trey Sermon, T.J. Pledger and Marcelias Sutton getting an increased number of carries, along with quarterback Kyler Murray seeing his share of carries. Sermon had some big games last season before Anderson emerged. The good news is the backfield depth is more than adequate. So, who emerges?

Iowa State: Running back David Montgomery is a stud, but he rushed for just 44 yards at about 2.6 yards per attempt against Iowa. That's less on Montgomery and more on the lack of available threats around him. Quarterback Kyle Kempt has a knee injury that may prevent him from playing, too (Zeb Noland would get the start in that case). Can the Cyclones' offense open up at all? Because right now it's in a tough place with a likely shootout necessary. 

Game prediction, picks

An early kickoff in Ames has "catch Oklahoma napping" potential, but the early evidence strongly suggests the visiting Sooners can handle this game. They've handled business against FAU and UCLA already. You have to score a lot of points to beat Oklahoma, so can the Cyclones get into the 30s, at least? Otherwise, Oklahoma might run away with another one. Pick: Oklahoma -18.5

What college football picks can you make with confidence in Week 3? And what team delivers a massive upset? Visit SportsLine to see which teams are winning more than 50 percent of simulations, all from a proven computer model on an 11-2 run that has returned over $4,000 in profit over the past three seasons.

CBS Sports Writer

Ben Kercheval joined CBS Sports in 2016 and has been covering college football since 2010. Before CBS, Ben worked at Bleacher Report, UPROXX Sports and NBC Sports. As a long-suffering North Texas graduate,... Full Bio

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