On the 50th anniversary of the "Game of the Century," the Oklahoma Sooners and Nebraska Cornhuskers renew their rivalry on Saturday at Memorial Stadium in Norman, Okla. On Nov. 25, 1971, No. 1 Nebraska edged No. 2 Oklahoma, 35-31, before a then-record 55-million plus television viewers. To celebrate that game, these former conference rivals decided to play for the first time since the 2010 Big 12 Championship Game. The Sooners (2-0) are ranked No. 3 in the country and feature one of the best quarterbacks in the nation in Spencer Rattler. Meanwhile the Cornhuskers (2-1) have rebounded with two blowout wins after dropping their season opener against Illinois

Kickoff is noon ET. The Sooners are 22.5-point favorites in the latest Oklahoma vs. Nebraska odds from Caesars Sportsbook, while the over-under for total points scored is 62.5. Before making any Nebraska vs. Oklahoma picks, make sure to check out the college football predictions and analysis from SportsLine's proven computer projection model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of more than $3,500 for $100 players on its top-rated college football picks against the spread. It also enters Week 3 of the 2021 season on a 67-50 run on all top-rated college football picks. Anyone who has followed it has seen huge returns.

Now the model has dialed in on Oklahoma vs. Nebraska and just revealed its picks and predictions. You can head to SportsLine now to see the model's picks. Now, here are several college football odds and betting trends for Nebraska vs. Oklahoma: 

  • Oklahoma vs. Nebraska spread: Sooners -22.5
  • Oklahoma vs. Nebraska over-under: 62.5 points 
  • Oklahoma vs. Nebraska money line: Sooners -2000, Cornhuskers +1000 
  • OU: Rattler ranks second in the country in completion percentage (76.9) 
  • NEB: WR Samori Toure ranks second in the nation in receiving yards (306). 
Featured Game | Oklahoma Sooners vs. Nebraska Cornhuskers

Why the Sooners can cover

Oklahoma has arguably the No. 1 offense in the country. The Sooners lead the nation in scoring offense (58.0 points per game) and rank 18th in total offense (527.0 yards per game). A large part of their success has come through the air; they lead the Big 12 and rank 16th in the country in passing yards per game (330.5).

In addition, Oklahoma will be facing a Nebraska team that failed miserably in its only other road test this season. In the Huskers' season-open loss at Illinois, Nebraska put in an error-filled performance, which included a safety on special teams, a fumble that was returned for a touchdown and two missed extra-point attempts. In their last 18 road games, the Huskers are just 4-14.

Why the Cornhuskers can cover

Nebraska has a veteran quarterback in Adrian Martinez. A 6-foot-2 junior from Fresno, Calif., Martinez ranks second in the Big Ten and 13th in the country in total offense (328.0 yards per game). He is one of just five players in Big Ten history to pass for 6,000 yards and rush for 2,000 more in his career.

In addition, the Cornhuskers face an Oklahoma team that has struggled in the kicking game this season. The Sooners are allowing 16.0 yards per punt return and 23.2 yards per kickoff return. Those rank 118th and 100th in the country, respectively.

How to make Oklahoma vs. Nebraska picks

SportsLine's model is leaning under on the point total, projecting the teams to combine for 62 points. The model also says one side of the spread hits in almost 60 percent of simulations. You can only get the model's Oklahoma vs. Nebraska pick at SportsLine

So who wins Nebraska vs. Oklahoma? And which side is covering almost 60 percent of the time? Visit SportsLine now to see which side of the Oklahoma vs. Nebraska spread to jump on, all from the advanced model that is on a 67-50 run on top-rated picks, and find out.