LSU coach Ed Orgeron's farewell tour begins on Saturday when his LSU Tigers take on the No. 12 Ole Miss Rebels in the SEC on CBS game on Saturday at Vaught-Hemingway Stadium in Oxford, Miss. On Sunday -- just 21 months after winning the national championship and completing one of the greatest single seasons in college football history -- LSU announced that the school will part ways with Orgeron at the end of the season. The Tigers (4-3, 2-2 in SEC) are just 9-8 since winning the national title. On Saturday they face their fourth straight Top 25 opponent -- an Ole Miss team (5-1, 2-1) that has lost only to Alabama. Ole Miss quarterback Matt Corral is questionable with an ankle injury. 

Kickoff is 3:30 p.m. ET. The Rebels are nine-point favorites in the latest Ole Miss vs. LSU odds from Caesars Sportsbook, while the over-under for total points scored is 77. Before making any LSU vs. Ole Miss picks, be sure to see the college football predictions and betting advice from SportsLine's proven computer model

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of almost $3,700 for $100 players on its top-rated college football picks against the spread. It also enters Week 8 of the 2021 season on a 22-9 run on all top-rated college football side picks. Anyone who has followed it has seen huge returns.

Now the model has dialed in on Ole Miss vs. LSU and just revealed its CFB picks and predictions. You can head to SportsLine now to see the model's picks. Now, here are several college football odds and betting lines for LSU vs. Ole Miss:  

  • Ole Miss vs. LSU spread: Rebels -9
  • Ole Miss vs. LSU over-under: 77 points 
  • Ole Miss vs. LSU money line: Rebels -350, Tigers +280
  • MISS: QB Matt Corral ranks third in the country in total offense (363.0 yards per game) 
  • LSU: LB Damone Clark leads the nation in tackles per game (11.3)
Featured Game | Ole Miss Rebels vs. LSU Tigers

Why the Rebels can cover

Ole Miss has one of the most prolific offenses in the country. The Rebels average 553.0 yards per game, which leads the SEC and ranks third in the country. They also average 43.7 points per game, which is second in the conference and fifth in the nation.

In addition, Sam Williams has the ability to get pressure on LSU quarterbacks. A 6-foot-4 senior from Montgomery, Ala., Williams leads the SEC and ranks fifth in the country in sacks per game (1.08) this season. Last week he had seven tackles, including 2.5 tackles for loss and 1.5 sacks, at Tennessee.

Why the Tigers can cover

Orgeron has a record of success against his former team. Orgeron, who went 10-25 in three seasons as head coach in Oxford (2005-07), is 5-0 against the Rebels, all as coach at LSU. The Tigers' average margin of victory in those five games has been 17.6 points a game.

LSU has finally gotten its ground game in gear as well. Running back Tyrion Davis-Price failed to top 51 yards in his first five games of the season. He's exploded in the last two games, however, rushing for 147 yards and two scores against Kentucky and then following that up with a record-breaking 36-287-3 rushing line in the upset win over Florida last week. 

How to make Ole Miss vs. LSU picks

SportsLine's model says the game stays under on the point total, projecting the teams to combine for 72 points. It also has an against-the-spread pick that cashes in well over 50 percent of simulations. You can only see the model's LSU vs. Ole Miss pick at SportsLine.

So who wins LSU vs. Ole Miss? And which side is covering well over 50 percent of the time? Visit SportsLine now to see which side of the Ole Miss vs. LSU spread to jump on, all from the advanced model that is on a 22-9 run on top-rated picks, and find out.