Buffalo's first drive stalled at their 45-yard line when Christian Braswell picked off a Matt Myers' pass. Anthony Russo then led the Owls (2-1) on a 12-play drive, capped by his 2-yard touchdown toss to Isaiah Wright. The Bulls (2-2) scored the next 24 points.
A fumbled punt led to Patterson's 4-yard touchdown run. Ledarius Mack sacked Russo and forced a fumble, and the Bulls scored three plays later on Myer's 7-yard TD run. Patterson ran for 52 yards on nine carries, and Kevin Marks capped that drive with a 9-yard touchdown run to end the half with the Bulls up 24-7.
Patterson ran it in from the 3-yard line in the third quarter and Joey Banks returned an interception 46 yards for a score to push Buffalo's lead to 38-10 with 9:43 remaining.
Russo finished 18-of-40 passing for 190 yards with two touchdown passes and three interceptions for the Owls.
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