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A Big Ten battle is on tap Saturday between the Indiana Hoosiers and the No. 8 Penn State Nittany Lions at 3:30 p.m. ET at Memorial Stadium. The Hoosiers are 1-9-1 against the spread in their last 11 games as a home underdog. The Nittany Lions, meanwhile, are 4-1 against the spread in their last five road games.

Penn State has dominated this rivalry over the years, winning nine of the last 10 meetings between these two programs. The Nittany Lions are favored by 6.5-points in the latest Indiana vs. Penn State odds from William Hill, and the over-under is set at 62. Before you make any Penn State vs. Indiana picks, check out the college football predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past four-plus years, the proprietary computer model has generated a stunning profit of over $4,100 for $100 players on its top-rated college football picks against the spread. It is a sizzling 25-13 on top-rated picks through seven weeks of the 2020 college football season, returning over $700 in profit already. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Penn State vs. Indiana. You can visit SportsLine now to see the picks. Here are the college football odds from William Hill and trends for Indiana vs. Penn State:

  • Penn State vs. Indiana spread: Penn State -6.5
  • Penn State vs. Indiana over-under: 62 points
  • Penn State vs. Indiana money line: Penn State -220, Indiana +190

What you need to know about Penn State

The Nittany Lions finished the 2019 season with an 11-2 record, including a 53-39 win against Memphis in the Cotton Bowl. That marked Penn State's third 11-win season from 2016 to 2019. Future NFL linebacker Micah Parsons opted out of the 2020 season, denting what is projected to be a strong defense.

New offensive coordinator Kirk Ciarrocca will look to steady a unit that was either feast or famine in 2019: the Nittany Lions scored more than 40 points four times and fewer than 20 points three times. Losing running back Journey Brown (knee) for the season will certainly hurt, and quarterback Sean Clifford will need to identify reliable receivers early in the season. Last season, Clifford threw for 2,654 yards, 23 touchdowns and seven interceptions.

What you need to know about Indiana

Coach Tom Allen directed the Hoosiers to an 8-5 record in 2019. Quarterback Michael Penix Jr. was brilliant when healthy, and he returns as the undisputed QB1 in Bloomington. Twelve of Indiana's top 19 tacklers last season were freshmen and sophomores, which will pay major dividends in 2020. Safety Marcelino Ball is already gone for the season with a preseason knee injury, but eight linemen and linebackers who made at least four tackles for loss last year return, as do four experienced safeties. 

The Hoosiers enter Saturday's matchup having covered the spread in seven of their last 10 games. Indiana is also 5-2 in its last seven games against Big Ten opponents. 

How to make Penn State vs. Indiana picks

SportsLine's model is leaning under on the total, and it has also generated an against-the-spread pick that hits in well over 60 percent of simulations. You can only get the pick at SportsLine.

So who wins Penn State vs. Indiana? And which side of the spread hits well over 60 percent of the time? Visit SportsLine now to see which side of the Indiana vs. Penn State spread to jump on Saturday, all from the advanced model that is up over $4,100 on its top-rated college football spread picks, and find out.