Presbyterian (2-10) racked up a 28-0 lead by early in the second quarter and blanked the Knights 17-0 after halftime.
Tyler Huff passed for two TDs in the first quarter for the Blue Hose, Jarius Jeter scored on a 3-yard run and Noah Suber scored on a fumble recovery before Presbyterian allowed a point.
Colby Campbell set a Big South Conference record for tackles in a season with 167 total tackles for the Blue Hose.
Keith Pearson had 10 catches for a career-high 138 yards with two scores. Jeter added 99 yards rushing and two TDs.
Kacy Otto passed for 128 yards and a TD for St. Andrews.
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