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A Big Ten battle is on tap between the Purdue Boilermakers and the Northwestern Wildcats at noon ET on Saturday at Wrigley Field. Purdue is 6-4, while Northwestern is 3-7. Purdue leads the all-time series between these programs with a 51-33-1 record.

The Boilermakers are favored by 12 points in the latest Northwestern vs. Purdue odds from Caesars Sportsbook, and the over-under is set at 48.5. Before entering any Purdue vs. Northwestern picks, you'll want to see the college football predictions from the model at SportsLine.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of almost $3,500 for $100 players on its top-rated college football picks against the spread. It also enters Week 12 of the 2021 season on a 36-23 run on all top-rated college football side picks. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Northwestern vs. Purdue. You can head to SportsLine to see its picks. Here are several college football odds for Purdue vs. Northwestern:

  • Northwestern vs. Purdue spread: Purdue -12
  • Northwestern vs. Purdue over-under: 48.5 points

What you need to know about Northwestern

The Wildcats found themselves the reluctant recipients of an unpleasant 35-7 loss against the Wisconsin Badgers last Saturday. Northwestern was in a tough position by the half, with the score already sitting at 21-0. The losing side was boosted by WR Stephon Robinson Jr., who caught five passes for 80 yards.

The loss was the fourth straight game that the Wildcats have scored two or fewer touchdowns. As a result of its offensive struggles, Northwestern ranks last in the Big Ten with just 17.1 points per game. One bright spot on that side of the ball has been the play of RB Evan Hull, who surpassed 1,000 yards from scrimmage in his last game.

What you need to know about Purdue

Meanwhile, things couldn't have gone much worse for Purdue as it lost 59-31 to the Ohio State Buckeyes on Saturday. Purdue was down 52-31 at the end of the third quarter, which was just too much to recover from. RB King Doerue had a tough game: he fumbled the ball once with only 26 yards rushing.

On offense, the Boilermakers go-to player is junior wide receiver David Bell. He leads the Big Ten with 1,106 receiving yards and that mark ranks fifth in the NCAA. In two career games vs. Northwestern, Bell has 23 catches for 193 yards and a score.

How to make Purdue vs. Northwestern picks

The model is leaning under on the total, and it's also generated a point-spread pick that is hitting in well over 60 percent of simulations. You can only see the pick at SportsLine.

So who wins Purdue vs. Northwestern? And which side of the spread hits well over 60 percent of the time? Visit SportsLine now to see which side of the spread you need to be all over, all from the model that has crushed its college football picks.