Kai Henry ran for 130 yards and two touchdowns and Canaan Brooks had 113 yards and a TD for the Coyotes (4-6, 3-3 Missouri Valley), who rushed for 327 yards. Simmons added 180 passing yards for a total offense of 507.
South Dakota led 35-14 at halftime on three touchdown passes by Simmons, a rushing touchdown by Simmons and a short TD run by Henry. The Coyotes scored the first three touchdowns of the second half and led 56-14 until late in the fourth quarter.
Joe Craycraft completed 18 of 30 passes for 246 yards and three touchdowns under heavy pressure for the Penguins (5-5, 1-5). He was sacked six times.
Both teams had double-digit penalties for triple-digit yards (Youngstown State 10 for 103; South Dakota (13 for 124).
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